The Meaning of Nucleocytoplasmic Transport (Molecular Biology Intelligence Unit) （2013. viii, 200 S. VIII, 200 p. 5 illus. 254 mm）

Agutter, Paul S./ Taylor, Philip L.

SPRINGER, BERLIN（2013発売）

SPRINGER, BERLIN（2013発売）

• 製本 Paperback:紙装版/ペーパーバック版
• 商品コード 9783662225042

Full Description

The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the intricate architecture of the nuclear pore-complex, the mechanisms by which transport substrates are sorted, and the supply of energy for exchange processes. This book attempts a general review of the growing body of knowledge. However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.

Contents

1. Perspectives in Transport.- 2. The Vagaries of Diffusion.- 3. Cellular Structures and Nucleocytoplasmic Transport.- 4. Events at the Pore-Complex.- 5. Events Involving the Nucleoskeleton and Cytoskeleton.- 6. Regulation and Pathologies of Nucleocytoplasmic Transport.- 7. Evaluation of a Model.