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The war against diabetes and improvement on insulin therapy since it was first administered in early of 20th century is still going to find the better option to cure the metabolic disorder. Remarkable progress made to date in regard to discovery of peptide hormones like recombinant insulin, insulin analogues, oral insulin and inhaler insulin. But insulin therapy to the patients for long periods resulted in immunological complications due to the development of insulin antibodies that cause insulin allergy and many chronic disorders. Management of diabetes without any side effects is still a challenge to the medical community. Therefore, it is prudent to look for options in herbal medicine. Over the past decade, numerous studies have been conducted to investigate the presence of insulin-like protein in non pancreatic organism. From a formidable amount of research, strongly suggest that plants, fungi, green algae and cyanobacteria produce a protein with most of the characteristics of vertebrate insulin and plays similar roles in plants as it does in animals.
