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Full Description
Natural product chemistry has undergone an explosive growth during the latter half of the current century. This has been brought about by a number of factors. One of these has been the growing number of sub stances from natural sources which display interesting pharmacological activities. These include antibiotics, anti-tumor agents, immunostimu lants, drugs affecting the cardiovascular and central nervous systems, analgesics etc. Another factor has been the improvements made in the technology of isolation processes which includes the development of such techniques as high pressure liquid chromatography which has al lowed the rapid isolation of substances which were previously diffi cult to obtain by classical procedures. The most important factor has been the development of new spectrosopic techniques which have opened up whole new vistas in this exciting field. Prominent in these advan ces has been the advent of powerful superconducting magnets with very stable magnetic fields, and pulse NMR in which the duration, direction and phases of pulses can be accurately controlled by means of mini computers. These have heralded the advent of two-dimensional NMR spec troscopy which has now come to be routinely employed in unravelling complex structures. No less important, though somewhat less dramatic, have been the advances made in the field of mass spectroscopy where new ionization techniques such as positive and negative fast atom bom bardment, field desorption, chemical ionization etc. have allowed the mass spectra of larger non-volatile substances to be recorded. The field of organic synthesis has seen equally rapid advances.
Contents
Applications of NMR in Biochemistry and Biosynthesis.- NMR Techniques for the Structure Elucidation and Conformational Analysis of Natural Products.- NMR Solutions to Problems of Connectivity in the Structural Elucidation of Natural Products.- Newer Applications of Circular Dichroism in Natural Products Chemistry.- Novel Carbohydrate Transformations Discovered en route to Natural Products.- New Reagents and Methods for the Synthesis of ß-Lactams, Peptides and Oligonucleotides.- General Strategies for the Asymmetric Synthesis of Oxygenated Natural Products.- Total Synthesis of Nitrogen-Containing Natural Products via Nitroso Diels-Alder Reaction.- Synthetic Studies in the Alkaloid Field.- Recent Progress in Our Indole Alkaloid Synthesis.- Synthetic Approaches to Carbazole Alkaloids.- Isoquinoline Alkaloid Synthesis via Arynes.- Biosynthetic Studies of Protoberberine and Related Alkaloids Using Plant Cell Cultures.- Secondary Metabolism in Cell Cultures of Some Terpenoid-Indole Alkaloid Producing Plants.- Synthetic, Multi-Deuteriated Cholesterol as a Quantitative Probe of the Formation of Cholesterol Oxidation Products.- Discovery and Chemistry of Naturally-Occurring Anticancer Agents.- Stereochemical Studies on Pre-anthraquinones and Dimeric Anthraquinone Pigments.- Peptide Siderophores from Pseudomonas.- Structure of Amavadin, the Vanadium Compound of Amanita muscaria and Selective Binding of Vanadium.- Micro-chemical Research Pattern and the Prospects of Its Industrial Development in the Developing Countries.- Isolation and Structural Studies on New Natural Products of Potential Biological Importance.- Isolation and Structural Studies on Chemical Constituents from Some Plants and Marine Organisms of Pakistan.
