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Full Description
Translation, i.e. protein synthesis, studied from a genetic viewpoint is illustrated in this volume, demonstrating how researchers are employing both classical genetic and recombinant DNA techniques in studying the components, mechanisms, regulation and accuracy of protein synthesis. Both the prokaryotic (especially Escherichia coli) and eukaryotic (especially Saccharomyces cerevisiae) system are discussed, presenting both new information and the new genetic approaches available. This book does not concentrate on one particular aspect of translation, but provides an ideal overview of the genetic approaches for dissecting the translation process as well as the current rapid advances made in the field through the use of in vitro genetics.
Contents
1: Integration of the Ribosome Cycle in Bacterial Cell Physiology.- Ribosomal RNA.- 2: Probing Ribosome Function Through Mutagenesis of Ribosomal RNA.- 3: Antibiotic Resistance Mutations in Escherichia coli Ribosomal RNA Genes and Their Uses.- 4: Feedback Regulation of rRNA Synthesis in Escherichia coli.- 5: Control of RNA Synthesis in Bacteria.- 6: Mechanism, Activation and Control of rRNA Transcription in E. coli.- 7: Specificity in RNA Processing Reactions in Escherichia coli.- Ribosomal Proteins.- 8: Molecular Mechanisms of the Antogenous Control of the S10 Ribosomal Protein Operon of Escherichia coli.- 9: Coordinate Control of Ribosomal Protein Gene Expression in Yeast.- 10: Genetic Analysis of Yeast Ribosome Biogenesis and Function.- 11: Thoughts on the Phosphorylation of a Ribosomal Protein.- 12: A Genetic Approach to Molecular Interactions in the Yeast Mitochondrial Ribosome.- 13: MIM3 and nam3 Omnipotent Suppressor Genes of the Yeast S. cerevisiae Affect the Polypeptide Composition of the 37S Mitoribosomal Subunit.- 14: Probing the Evolution of the Translational Apparatus with Archaebacterial Ribosomes.- Transfer RNA.- 15: trpA and Its Protein: Something Old, Something New.- 16: Genetic and Regulation of tRNA Methyltransferases in Escherichia coli.- 17: Identification and Characterization of Mitochondrial and Nuclear Gene Products and Genes Necessary for Mitochondrial tRNA Biosynthesis in Saccharomyces cerevisiae.- 18: Suppressors, Introns and Stage Specific Expression of tRNATyr Genes in Drosophila melanogaster.- Translation Fractors.- 19: The Structure and Expression of DNAs Encoding Initiation Factors from Bacterial and Mammalian Cells.- 20: The Polypeptide Chain Elongation Factor Tu: Characterisation of Mutants and Protein Engineering.- 21: The Analysis ofTemperature-Sensitive Mutants of Saccharomyces cerevisiae Altered in Components Required for Protein Synthesis.- 22: The Mitochondrial Release Factor and the Divergent Codes.- Mechanism Of Translation.- 23: How Does the E. coli Ribosome Know Where Translation Should Begin?.- 24: Translation Initiation in the Escherichia coli GalE Gene.- 25: Selection of mRNA by Ribosomes During Prokaryotic Translational Initiation.- 26: Single Point Mutations at the 5? End of a Eukaryotic Gene Can Affect Synthesis of of Gene Product in E. coli.- 27: A Novel Approach for Mutational Analysis of the 16S rRNA Molecule Using the Specialised Ribosome System in Escherichia coli.- 28: Structural Features of mRNA That Affect Translation in Yeast.- 29: Translation Initiation in Yeast: A Genetic and Mutational Analysis.- 30: Multiple Nuclear Gene Products are Specifically Required to Activate Translation of a Single Yeast Mitochondrial mRNA.- Accuracy of Translation.- 31: Effects on Suppressor tRNAs by Mutated Ribosomes -Lack of Correlation With Their Effects on Translational Misreading.- 32: Genetic Control of tRNA Suppression in Saccharomyces cerevisiae: Allosuppressors.- 33: Omnipotent Suppressors, Allosuppressors and Antisuppressors of Yeast.- 34: Translational Frameshifting and Codon Recognition.- 35: Genetics of Ribosomes and Translational Accuracy in Podospora anserina.- Translational Control.- 36: Initiation Complex Formation: A Simple Assay for Translational Regulation.- 37: Expression of atp Genes in Escherichia coli.- 38: Translational Control in E. coli: The Case of Threonyl-tRNA Synthetase.- 39: Translationally Controlled Expression of the Overlapping Lysis Gene in RNA Phage MS2.- 40: Translational Control of Transcriptional Activation in the Regulation of Amino Acid Biosynthesis inYeast.- Participants and Contributors.
