Full Description
Main focus of the new book will be the description and discussion of rat and mouse models for organ transplantation. Various microsurgical techniques will be presented which allow transplantation of functional organs in syngeneic systems. In particular, the extremely difficult methods necessary for organ transplantation in mice will be presented and evaluated. Besides these practical aspects the book will also cover the theoretical sides of organ transplantation like the immunobiology of allotransplantation. Special emphasis will be given to the resurgent field of xenotransplantation. The results from xenograft models developed in the recent years using rats or mice will be reviewed and their impact on future human xenotransplantation will be discussed.
Contents
Introduction.- Requirements for transplantation research in small animals.- Basic techniques in rats.- Basic techniques in mice.- Immunological concepts and techniques for research in small animals.- Results of vascular and cardiac transplantation.- Results of small bowel transplantation, GVHR + HVGR.- Pancreas and islet transplantation.- Liver transplantation.- Xenotransplantation.- Results in mice.
