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Full Description
This book was written, to a not inconsiderable degree, on the basis of the course "The Problems of Modern Biophysics" which the author gives to the students and postgraduates of the Biophysical Department at Moscow University School of Physics. It is meant for those who have a sufficiently good background in physics as well as in biology. I have tried to make this book intelligible to a broader circle of readers, i.e., to physicists not competent enough in biology, and to biologists not competent enough in physics. I hope that I have succeeded. This book is neither a textbook nor a systematic account of a field of science. I think that in modern biological physics, i.e., in the branch of biology where people having fundamental physical or physico-chemical education are working, so many specific answers have been recently obtained that it is now just the right time to ask at least several questions of a general nature. The aim of this book is to formulate such questions though their choice is, to a considerable degree, determined by the authors preferences and interests.
Contents
1. Introduction.- 1.1 What is Biophysics?.- 1.2 Cell Components and Their Specific Features.- 1.3 The Aim of the Book.- 2. The Ordering of Biological Structures.- 2.1 Are They so Ordered in Reality?.- 2.2 Entropy and Information.- 2.3 What is the Cost of Biological Ordering?.- 2.4 The Meaning of Biological Ordering.- 2.5 The Necessity of Mechanical Details.- 2.6 The Problems.- 3. Nonequilibrium Thermodynamics and Biological Physics.- 3.1 Open Systems.- 3.2 Phenomenological Relations.- 3.3 Stationary States.- 3.4 Dissipative Structures.- 3.5 Oscillatory Phenomena in Chemistry and Biochemistry.- 3.6 The Problems.- 4. On the Statistical Physics of Biopolymers.- 4.1 Where does Mechanics Begin?.- 4.2 Statistical Physics of a Linear Homopolymer.- 4.3 On the Statistical Nonequilibrium of Biopolymer Structures at Different Levels of Organi zation.- 4.4 On Certain Properties of Biopolymer Structures that Can Be Understood in Terms of Their Statistical-Physical Description.- 5. Conformational and Configurational Changes of Biopolymers.- 5.1 Introductory Remarks.- 5.2 Biopolymer Denaturation.- 5.3 On the Difference Between Activation Energy and Activation Enthalpy.- 5.4 Some Protein Reactions.- 5.5 On the Compensation Effect.- 5.6 On the Validity of the Van't Hoff and Arrhenius Equations and of the Activated State Theory for Biopolymer Reactions.- 5.7 On Spontaneous Conformational Oscillations of Protein Macromolecules.- 5.8 Conclusions.- 6. The Physics of Enzyme Catalysis.- 6.1 Background.- 6.2 Existing Interpretations of Enzymatic Activity.- 6.3 Conformational Changes as Necessary Steps of Enzymatic Processes.- 6.4 The Effect of Temperature on Enzymes and on the Activation Parameters of Enzyme Reactions.- 6.5 The Physics of Elementary Steps of Enzyme Catalysis [6.69,72,79,80].- 6.6 Dynamic Model for Aspartate-Amino-Transferase.- 6.7 Conclusions.- 7. The Physics of Electron Transfer in Biological Systems.- 7.1 Overview.- 7.2 Free Radicals and Radical Ions in Biochemical Reactions.- 7.3 Electron Transport Chains (ETC) in Mitochondrial and Chloroplast Membranes.- 7.4 Electron Transfer Reactions and Semiconduction in Biological Systems.- 7.5 On the Tunnelling Mechanisms of Electron Transfer Between the ETC Components.- 8. The Physics of Intracellular Energy Transformation and Accumulation.- 8.1 Overview.- 8.2 The ATP Problem.- 8.3 Substrate Phosphorylation.- 8.4 Membrane Phosphorylation: Thermodynamic Aspects.- 8.5 Membrane Phosphorylation: Existing Theories.- 8.6 Some Physical Aspects of Intracellular Energy Transformation as a Relaxation Process.- 9. Conclusion.- References.
