Description
UV radiation is recognized as the major risk factor for skin can cer. For the last three decades the incidence and mortality of skin cancer have been increasing steadily in almost all parts of the world. Unfortunately, there have been very few advances in the management and treatment of skin cancer. In comparison to other malignant tumors, skin cancer offers the unique opportuni ty to identify this tumor at an early stage. Thus, there is strong interest in preventing death by early diagnosis and prompt treat ment. The proceedings of the International Congress on Skin Cancer and UV Radiation which was held in Bochum Germany in October 1996, reflect the newest scientific standards in the field of skin cancer. The conference in Bochum was a platform for leading scientists from all over the world to discuss the complexity and diversity of UV radiation in its interaction with the skin. Starting with basic science like physiology, immunology, and molecular biochemistry of the skin as influenced by UV radiati on, the book presents a profound survey into the field of skin can cer by focusing on the latest scientific results in prevention, early detection, treatment, and epidemiology. The congress in Bochum in 1996 was organized to provide a starting point for coordinated European strategies against skin cancer with internationally renown scientists. Skin Cancer and UV Radiation in History of Medicine.- Sun and Men: An Ambivalent Relationship in the History of Medicine.- History of Therapeutic UV Radiation.- History of Skin Cancer.- UV Radiation and the Environment.- Basic Physical Aspects of Environmental UV Radiation.- UV Prognosis and UV Index Services in Europe.- Ozone Holes and UV Radiation: Ecological Consequences for Plants.- Public On-Line Information on Solar UV Irradiance Based on Spectrometric Measurements in a Sea Resort.- UV-Expert: A Spectroradiometric System for Individual UV Dosimetry.- Effects of UV Radiation on Human Skin.- MolecularBasics.- Basic Aspects of Collagen Metabolism.- Sunburn and Apoptosis.- Dermal Elimination of Apoptotic and Vital Melanocytes After UVA1 Radiation.- Importance of Calcium-Magnesium Antagonism and Thiols for Diminution of UVA1-Induced Cell Damage.- Molecular Role of Reactive Oxygen Species in Photoaging and Tumor Progression.- How Much Sun Do We Need To Produce Vitamin D?.- UV Radiation and Urocanic Acid.- Activation of Human Endogenous Retroviral Sequences by UVB.- Melanins,Pigmentation and Erythema.- Melanins and Related Metabolites in Skin Photoprotection.- Physiology of Skin Pigmentation: Recent Results.- Time Course of UV Erythema.- Measurement of Constitutive Skin Phototypes.- Photoprotection by Total Melanin Content and Pigment Phenotype (Eumelanin, Pheomelanin) in Human Melanoma Cell Lines.- Melatonin: Multiple Functions in Signaling and Protection.- Principles of Phototesting and Photopatch Testing.- Optics of Human Skin: UV Effects Investigated with Dye Lasers.- Quantitative Evaluation of the UV Reaction at 325 nm with a Two-Dimensional Laser Doppler Perfusion Imager.- Immunology.- UV Radiation and Cytokines.- Effect of UV Light on the Production of Proopiomelanocortin-Derived Peptides and Melanocortin Receptors in the Skin.- Cytokines, Cytokine Receptors and Cytokine Antibodies: Clinical Implications.- Mexoryl SX Protects Against Photoimmunosuppression.- UV Protection: Sunscreens and other UV Protective Measures.- The Evolution of Recent Sunscreen.- Sunscreens in Europe: Recent Developments.- UV Protection by Sunscreens.- Photostable Suncare Products: Major Progress in Sun Protection.- Evaluation of Sunscreens.- Regulations on Sunscreens.- Use and Misuse of Sunscreens.- Sunscreens in Melanoma Protection - Pros and Cons.- Influence of Sunscreen on the Spectral Energy Distribution of Ultraviolet Radiation in Human Skin.- Clothing as Protection Against the Sun.- Developing a United States Sun-Protective Clothing Standard.- New UV Absorbers for Sun Protective Fabrics.- Novel Approaches to Photoprotection.- Betacarotene in the Prevention of Chronic Ultraviolet Damage and Non-melanoma Skin Cancer.- Therapeutic Use of UV Radiation.- Balneophototherapy.- A New Psoralen-Containing Gel for Topical PUVA Therapy: Development and Treatment Results with Palmoplantar and Plaque-Type Psoriasis, Pustulosis Palmaris et Plantaria and Chronic/Hyperkeratotic Eczema.- PUVA, Psoralens and Skin Cancer.- PUVA Bath Therapy: A Therapeutic Alternative to Systemic Photochemotherapy.- Artifical Light Sources for Phototherapy.- Trioxsalen Bath PUVA Does Not Increase the Risk of Squamous Cell Skin Carcinoma: A Joint Analysis of 1124 Swedish and Finnish Patients Followed Up for 10 Years.- Photoaging and Other Side Effects Due to the Long-Term PUVA Therapy.- Evaluation of PUVA Bath Therapy for Sclerosing Dermatoses by in Vivo Measurement of Skin Elasticity Using Cutometer SEM 575.- Kinetics of 8-Methoxypsoralen - Induced Skin Photosensitization in PUVA Bath Photochemotherapy.- 8-Methoxypsoralen Plasma Levels in Patients with Different Dermatoses Following PUVA Bath Photochemotherapy.- A New Treatment Modality of Localized Scleroderma: Low-Dose UVAl Phototherapy.- Influences of UV Radiation in the Therapy of Psoriasis Vulgaris.- Assessment of Actinic Elastosis by 20 MHz Sonography.- Photopheresis as a Therapeutical Alternative for PUVA.- Extracorporea
