Fragment-Based Drug Discovery and X-Ray Crystallography (Topics in Current Chemistry) 〈Vol.317〉

Davies, T. G. (EDT)/ Hyvönen, M. (EDT)

Springer（2012/02発売）

• 製本 Hardcover:ハードカバー版／ページ数 225 p.／サイズ 57 illus., 31 in color
• 商品コード 9783642275395

基本説明

From the preface- We hope this book will provide a useful introduction to some of the key concepts and techniques in fragment-based drug discovery, highlighting the diverse set of targets it is applied to, as well as emphasizing the importance of structural information in this field. The application of X-ray crystallography to structure-based drug discovery is now a mature discipline, but one whose potential has sometimes been under-exploited. In driving various aspects of the fragment-based approach, it clearly plays a central role.

Full Description

Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson

Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle

Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard

Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. Stamford

Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter Huber

Targeting Protein-Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko Hyvönen

Fragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy Arnold

Fragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan

Contents

D. A. Erlanson
Introduction to Fragment-Based Drug Discovery.-

T. G. Davies
Ian J. Tickle
Fragment Screening Using X-Ray Crystallography.-

S. Roughley
L. Wright
P. Brough
A. Massey
R. E. Hubbard
Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening.-

D. F. Wyss
Y.-S. Wang
H. L. Eaton
C. Strickland
J.s H. Voigt
Z. Zhu
A. W. Stamford
Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors.-

M. Hennig
A. Ruf
Walter HuberCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery.-

E. Valkov
T. Sharpe
M. Marsh
Sa. Greive
M. Hyvönen
Targeting Protein-Protein Interactions and Fragment-Based Drug Discovery.-

J.h D. Bauman
D. Patel
E. Arnold
Fragment Screening and HIV Therapeutics.-

D. Rognan
Fragment-Based Approaches and Computer-Aided Drug Discovery.