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Description
Topoisomerase inhibitors constitute a type of chemotherapy utilized in treating specific forms of lung cancer. They function by obstructing enzymes responsible for DNA replication, thereby impeding cell division and inducing the death of cancer cells. DNA-topoisomerases, crucial for numerous biological functions, have garnered increased interest in recent years due to their pivotal role in facilitating DNA replication and transcription processes. Additionally, these enzymes serve as the target for various active components. The potential to develop a novel class of anticancer drugs lies in inhibiting the activity of these enzymes post-DNA damage and repair failure, leading to the therapeutic utilization of causing tumor cells to die. The blockade of topoisomerases hinders cell division, ultimately resulting in cell death. This mechanism explains why topoisomerase inhibitors are effective in killing cells that undergo faster division, such as cancer cells. Dr Eman Refaat Youness, MD, Medical Biochemistry, Faculty of Medicine, Cairo University; Prof. of Medical Biochemistry, National Research Centre, Egypt. Areas of interest: xperimental design, clinical researches, DNA, PCR. The author has international publications, and is a member of international societies, reviewer and editor of many journals.
