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Description
(Text)
The drug ±3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a popular recreational substance among young people. Most prior research has not attempted to carefully emulate human ecstasy use patterns in animal investigations. The objectives of the present series of experiments were to develop a rat model of intermittent ecstasy use and to begin to characterize the acute and long-term physiological, behavioral, and neurochemical consequences of adolescent MDMA exposure. These studies determined that: 1) repeated exposure to a clinically relevant MDMA dose can reduce cognitive function and alter affective behavior, 2) adolescent MDMA can lead to MDMA tolerance in adulthood, 3) the behavioral toxicology of MDMA may not be exclusively mediated by decreases in the serotonin transporter. Overall, these findings indicate that the enduring neurobiological consequences of MDMA may not be limited to the serotonergic system and have substantial public health implications for regular ecstasy users.
(Author portrait)
Piper, Brian Brian Piper, Ph.D. is a neuropharmacologist whose research has been published in the Journal of Pharmacology & Experimental Therapeutics and Neuropsychopharmacology. He teaches courses about recreational drugs at the University of Massachusetts. He is currently in Portland, Oregon studying children that were prenatally exposed to methamphetamine.
