基本説明
Contents: The Advantages and Limitation of Cell Culture as a Model of Bone Formaiton; Apoprosis in Bone Cells; Genetics in Osterporosis; Transgenic and Gene Knock-Out Animals in Skeletal Research Mechanotransduction; and more.
Full Description
Future treatments for osteoporosis will seek to heal it by improving bone mass and quality. This work describes discoveries and research which will allow bone to be restored after it has been lost.
Contents
The advantages and limitations of cell culture as a model of bone formation; the identification and isolation of cells of the osteoblast lineage in cultures of adult human bone-derived cells by dual labelling with the monoclonal antibodies STRO1 and B4-78; apoptosis in bone cells; genetics in osteoporosis; the regulation of bone cell and proliferation by transcription factors; transgenic and gene knock-out animals in skeletal research; mechanotransduction - an inevitable process for skeletal maintenance; the regulation of gene expression in bone by mechanical loading; amplification of the osteogenic stimulus of load-bearing as a logical therapy for the treatment and prevention of osteoporosis; novel aspects of parathyroid hormone/parathyroid hormone-related protein hormone-receptor interactions; bone morphogenic proteins - role, modes of action and potential significance in osteoporosis.
