Full Description
Focusing primarily on the development of effective gene therapy approaches for HIV infection, this text includes the improvement of gene transfer vectors; procedures for the ex-vivo manipulation and transduction of T-lymphocytes and haematopoietic stem cells; and preclinical testing of HIV inhibition strategies. It provides a perspective of the accomplishments in this field as well as the problems which need to be solved in order to develop safe therapies which benefit persons with HIV infection.
Contents
Replicative cycle of HIV; gene therapy strategies for inhibition of HIV; trans-splicing ribozymes as potential HIV gene inhibitors; viral vectors for HIV gene therapy; T lymphocyte-based HIV gene therapy strategies; stem cell-based gene therapies in the treatment of AIDS; animal models of gene therapy for AIDS; haematopoietic stem cell transplantation and HIV gene therapy.
