Dipeptidyl Peptidase IV (CD26) in Metabolism and the Immune Response (Molecular Biology Intelligence Unit)

Fleischer, Bernhard (EDT)

Springer-Verlag Berlin and Heidelberg GmbH & Co. K（1995/11発売）

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製本 Hardcover:ハードカバー版／ページ数 222 p.
言語 ENG
商品コード 9783540601999
DDC分類 574.8761

Full Description

In this text, leading experts in their field describe the enzymology and molecular biology of dipeptidyl peptidase IV-CD26 and its functions in metabolism and immune responses. CD26 is identical to the proteolytic enzyme dipeptidyl peptidase IV expressed in a variety of different tissues including epithelia and lymphocytes. CD26 binds and transports adenosine desaminase selectively in different tissues. It is also involved in T cell activation, providing stimulatory and co-stimulatory signals. It is a receptor for collagen and may be a marker for malignancy. Recent progress from a number of laboratories has shown that CD26/dipeptidyl peptidase IV plays an important role in the response of T lymphocytes and may be involved in the pathogenesis of AIDS.