Full Description
The coding domains of simple retrovirus genomes direct the synthesis of virion proteins. Complex retroviral genomes generate in addition to virion proteins regulatory transacting proteins that are translated from multiple spliced messenger RNAs and fulfill important functions in the virus life cycle. All human retroviruses have such complex genomes. The transacting proteins of these pathogens are attractive targets for therapeutic intervention because they are viral specific, are essential for efficient virus replication and may be mediators of viral pathogenicity. In summarizing the current knowledge on the regulatory transacting proteins of human retroviruses, this volume makes an important contribution toward the control of virus disease.
Contents
List of Contents.- Regulation of Foamy Virus Gene Expression.- Transactivation of Cellular Genes by Human Retroviruses.- Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by the Transactivator Protein Tat.- HTLV-1 Oncoprotein Tax and Cellular Transcription Factors.- The Human Immunodeficiency Virus Type 1 Rev Protein: A Pivotal Protein in the Viral Life Cycle.- The Human Immunodeficiency Virus Type 1 Vpu Protein: Roles in Virus Release and CD4 Downregulation.- Viral Protein X.- The Pathogenic Role of Human Immunodeficiency Virus Accessory Genes in Transgenic Mice.- The Human Immunodeficiency Virus Type 1 vif Gene: The Road from an Accessory to an Essential Role in Human Immunodeficiency Virus Type 1 Replication.- Nef.- The vpr Regulatory Gene of Human Immunodeficiency Virus.
