Retroviral Insertion and Oncogene Activation (Current Topics in Microbiology and Immunology)

Kung, Hsing-Jien (EDT)/ Vogt, Peter K. (EDT)

Springer-Verlag Berlin and Heidelberg GmbH & Co. K（1991/11発売）

• 製本 Hardcover:ハードカバー版／ページ数 188 p.
• 言語 ENG
• 商品コード 9783540538578
• DDC分類 571.6

Full Description

This book provides a comprehensive review of a key step involved in cancers induced by retroviruses - insertional mutagenesis and oncogene activation. Neoplastic diseases induced by avian, murine, feline and human retroviruses are reviewed in detail to illustrate the principles of these processes. The involvement of the individual oncogenes in tumorigenesis as well as in the normal growth pathway are analyzed. The mechanisms of oncogene activation and oncogene capturing by retroviruses are discussed. This monograph on microbiology and oncology is intended for researchers.

Contents

Retroviral Mutagenesis of Cellular Oncogenes: A Review with Insights into the Mechanisms of Insertional Activation. Mutagenesis of the Mouse Germline Using Retroviruses. Insertional Mutagenesis in Mouse Mammary Tumorigenesis. Feline Leukaemia Virus: Generation of Pathogeneic and Oncogenic Variants. Virus-Host Interactions and the Pathogenesis of Murine and Human Oncogenic Retroviruses.