Full Description
The administration of chemotherapeutic agents by continuous infusion with concomitant radiation therapy heralds a new approach in the treatment of cancer. This examination of the subject includes, besides a discussion of its scientific basis, the most promising clinical data on the use of continuous infusion chemotherapy and radiation. Thus, it is designed as an update for clinical investigators involved in frontline research as well as for practising physicians participating in the direct care of cancer patients. The book includes the latest results of this new approach in a number of tumour sites. There is a detailed description of the principles of radiosensitization for malignant tumours and radioprotection for normal tissues, and a presentation of the most recent data on the beneficial effects resulting from the administration of commonly used drugs, such as 5-fluorouracil, cisplatinum and adriamycin, with concomitant radiation therapy.
Contents
Contents: The Development of Chemotherapy Drugs as Radiosensitizers: an Overview.- Principles of Infusion Chemotherapy.- Radiosensitization and Radioprotection.- 5-Fluorouracil Radiopotentiation and Its Modulation by Other Agents.- Radiopotentiation by Cisplatin in Continuous Infusion.- Radiopotentiation by Combined Cisplatin and Continuous Infusion 5-Fluorouracil.- Efficacy of Continuous Infusion Adriamycin as a Radiation Potentiator.- Subject Index.- List of Contributors.
