Full Description
Hematopoietic stem cell and immune cell transplantation has cont- ued as a promising therapeutic alternative and a fascinating area of cell biology as well as a field of persistent procedural problems. This - plains why substantial parts of basic research on cell growth and d- ferentiation, immune tolerance and antitumor effects, gene transfer, minimal residual disease and supportive care have settled around cli- cal transplantation in hematology and oncology. This second volume again updates the current role of allogeneic and autologous transpl- tation in leukemias, lymphomas and solid cancers, including cont- versial strategies and novel experimental approaches. In particular, cellular immune therapy, new conditioning strategies, mismatched donor transplantation, updated clinical transplantation, antiangiogenesis and strategies against fungal infections are focused upon. Outstanding representatives of leading groups guarantee fir- hand information and indicate how we can work and cooperate more effectively to the benefit of our patients.
The editors are indebted to the Gesellschaft zur Bekampfung der Krebskrankheiten Nordrhein-Westfalen for a substantial support of the publication. They also acknowledge the major contribution of Beate Kosel as coordinator of the editorial work.
Contents
Cellular Therapy: Targets and Effectors.- Adoptive Immunotherapy in Chimeras.- The Roles of the Chemokine SDF-1 and its Receptor CXCR4 in Human Stem Cell Migration and Repopulation of NOD/SCID and B2mnull NOD/SCID mice.- Towards Adoptive Immunotherapy Using High Affinity T Cell Receptors.- New Antigens and Avenues to Immunotherapy of Cancer.- Allogeneic Cell Therapy with Antigen-Specific Cytotoxic T Lymphocytes (CTL) for Malignant Melanoma.- New Conditioning Strategies n Allogeneic Stem Cell Transplantation.- Intensification of the Conditioning Regimen for Patients with high-risk AML and MDS: 3 year Experience of using an188 Re — Labelled anti — CD 66 Monoclonal Antibody.- Dose Reduced Conditioning for Allogeneic Blood Stem Cell Transplantation from Sibling and Unrelated Donors in 51 Patients.- Pharmacokinetics of Conditioning Regimens.- Megadose Stem Cell Transplantation.- HD-Ara-C in the Conditioning Regimen for BMT in Acute Leukemias.- TBI-Based Reduced Intensity Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation (SCT) in Patients with High-Risk Hematologic Malignancies.- Total Marrow Irradation (TMI), Busulfan, and Cyclophos-phamide for Allografting in Multiple Myeloma. A Pilot Study.- Stem Cell Mobilisation, Processing and Characteristics.- A "Single" Delayed Application of G-CSF after Autologous Peripheral Blood Stem Cell Transplantation — A Pilot Study.- Factors Influencing PBPC Mobilisation and Collection in Haematological Malignancies.- Successful Purging of Stem Cell Products Using CD34 Selection.- Autologous Transplantation of Non-Cryopreserved HSCs in Oncologic Patients with Poor Prognosis: First Experience in the Ukraine.- A Randomized Comparison of Once Versus Twice Daily rhG-CSF (Filgrastim) for Stem Cell Mobilisation inHealthy Donors for Allogeneic Transplantation.- CD 133/CD34 Expression on Hematopoietic Stem-/ Progenitor Cells and Acute Leukemic Blasts.- Identification of Minimal Residual Leukemia Applying Continuous Gating.- Cord Blood Transplantation.- Pilot Study — Lymphocyte Subset Reconstitution after Cord Blood Transplantation.- Altered Growth Characteristics of Cord Blood after in vivo Exposure of the Mother to Chemotherapy.- Mismatched Donor Transplantation.- Bone Marrow Transplantation from Mismatched Unrelated Donors.- Immune Reconstitution after Haploidentical Stem Cell Transplantation.- Clinical Transplantation — Hematologic Malignancies.- Autografting and Allografting for Chronic Lymphocytic Leukemia: Is there a Rationale?.- Results of Stem Cell Transplantation in Children with CML in Comparison with Treatment with Cytostatics alone or with Interferon alfa. Report of the Polish Children's Leukemia/Lymphoma Study Group.- Comparison of Allogeneic Matched Related Stem Cell Transplantation in 1st CR with Chemotherapy alone in Children with High-Risk AML.- Stem Cell Transplantation in Acute Myeloid Leukemia after Conditioning with Busulfan, Cyclophosphamide and Different Dosages of Etoposide (VP-16).- The Occurrence of Acute Graft-Versus-Host Disease and Infectious Complications in Patients with Acute and Chronic Myeloid Leukemia who Underwent Allogeneic Peripheral Blood Stem Cell Transplantation.- Long-Term Survival after Stem Cell Transplant in Adult Acute Lymphoblastic Leukemia.- Clinical Transplantation — Solid Tumors.- Autologous Transplantation in Breast Cancer in Europe and EBMT Data.- First-Line and Salvage High-Dose Chemotherapy in Patients with Germ-Cell Tumors.- High Dose Chemotherapy in High-Risk Ewing Tumours: Results in 156 (EI)CESS Patients.- RapidSequence Tandem Transplant in Children with High-Risk Neuroblastoma.- Anti-Angiogenesis.- Angiogenesis Inhibitor TNP-470 During Bone Marrow Transplant and in Minimal Residual Disease.- Challenges in the Treatment of Fungal Infections.- Prophylaxis of Fungal Infections in Neutropenic Patients with Hematologic Malignancies.
