心血菅薬理遺伝学<br>Cardiovascular Pharmacogenetics (Handbook of Experimental Pharmacology Vol.160) (2004. X, 407 p. w. 34 figs. 24,5 cm)

個数:
  • ポイントキャンペーン

心血菅薬理遺伝学
Cardiovascular Pharmacogenetics (Handbook of Experimental Pharmacology Vol.160) (2004. X, 407 p. w. 34 figs. 24,5 cm)

  • ウェブストア価格 ¥81,563(本体¥74,149)
  • SPRINGER, BERLIN(2004発売)
  • 外貨定価 EUR 534.99
  • シルバーウィーク秋の全店ポイント2倍キャンペーン
  • ポイント 1,482pt
  • 在庫がございません。海外の書籍取次会社を通じて出版社等からお取り寄せいたします。
    通常6~9週間ほどで発送の見込みですが、商品によってはさらに時間がかかることもございます。
    重要ご説明事項
    1. 納期遅延や、ご入手不能となる場合がございます。
    2. 複数冊ご注文の場合、分割発送となる場合がございます。
    3. 美品のご指定は承りかねます。

  • ウェブストア価格 ¥77,679(本体¥70,618)
  • SPRINGER, BERLIN(2004発売)
  • 外貨定価 US$ 599.99
  • シルバーウィーク秋の全店ポイント2倍キャンペーン
  • ポイント 1,412pt
  • 提携先の海外書籍取次会社に在庫がございます。通常2週間で発送いたします。
    重要ご説明事項
    1. 納期遅延や、ご入手不能となる場合が若干ございます。
    2. 複数冊ご注文の場合、分割発送となる場合がございます。
    3. 美品のご指定は承りかねます。
  • 【重要:入荷遅延について】
    各国での新型コロナウィルス感染拡大により、洋書・洋古書の入荷が不安定になっています。
    弊社サイト内で表示している標準的な納期よりもお届けまでに日数がかかる見込みでございます。
    申し訳ございませんが、あらかじめご了承くださいますようお願い申し上げます。

  • 製本 Hardcover:ハードカバー版/ページ数 350 p.
  • 商品コード 9783540402046

基本説明

Contents: The Role of Genotyping in Pharmacological Therapy.- Pharmacogenetics and the Treatment of Cardiovascular Disease.- Genetic Polymorphisms and Cardiovascular Drug Metabolism.- Genes that Modify Susceptibility to Atherosclerosis.- and more.

Full Description


The Human Genome Project was sold to the general public largely on the basis that a complete picture of the structure of human DNA would lead to new and better medicines. These medicines would be better because they would be tailored to individual patients, maximising the chances of a therapeutic response and mi nimising the risks of an adverse event. Taking the idea further, pundits have pre dicted that the time will come when we could carry our DNA on a card which could be read rapidly and enable the physician to choose the best drug. This is the future. This is pharmacogenetics. When the draft human DNA sequence was announced and scientists were as ked how this would help drug development, the example most frequently given was the debrisoquine model - where poor metabolisers of this hypotensive agent are exposed to higher plasma levels from a standard dose and at risk of collapse from excessive hypotension. This observation was made over 20 years ago and predated designs to sequence the human genome. Nonetheless, it raised aware ness of variation in drug metabolism and was correctly assigned to genetic poly morphisms affecting CYP2D6. Together with the discovery of pseudocholinestera se deficiency, it marked the birth of pharmacogenetics. The debrisoquine example is an interesting one and worthy of further analysis.

Table of Contents

The Role of Genotyping in Pharmacological          1  (24)
Therapy
K. Lindpaintner
Pharmacogenetics and the Treatment of 25 (14)
Cardiovascular Disease
S.K. Tate, D.B. Goldstein
Genetic Polymorphisms and Cardiovascular Drug 39 (40)
Metabolism
A.R. Boobis, T. Shiga, R.J. Edwards
Genes That Modify Susceptibility to 79 (28)
Atherosclerosis: Targets for Drug Action
J.W. Knowles
Lipid-Lowering Responses Modified by Genetic 107(42)
Variation
B.R. Winkelmann, M.M. Hoffmann, W M舐z
The Genetic Basis of Essential Hypertension and 149(28)
Its Implications for Treatment
K.M. O'Shaghnessy, M.R. Wilkins
Genetic Predisposition to Cardiac Hypertrophy 177(26)
A.J. Marian
Genetic Determinants of Susceptibility, 203(20)
Prognosis and Treatment in Heart Failure
T. Stanton, J.M.C. Connell, J.J.V. McMurray
The Genetics of Cardiac Channelopathies: 223(20)
Implications for Therapeutics
D.M. Roden
Insulin Resistance and Cardiovascular Disease: 243(38)
New Insights from Genetics
A. Vidal-Puig, E.D. Abel
Genetic Disruption of Nitric Oxide Synthases 281(30)
and Cardiovascular Disease: Lessons from a
Candidate Gene
P.L. Huang
Association of Thrombotic Disease with Genetic 311(12)
Polymorphism of Haemostatic Genes: Relevance to
Pharmacogenetics
E.G.D. Tuddenham
The Influence of Genetic Factors on Leukocyte 323(18)
and Endothelial Cell Adhesion Molecules
R.M. Rao, A.I. Russell, T. Vyse, D.O. Haskard
Genetic Regulation of Metalloproteinase 341(18)
Activity: Pathogenic and Therapeutic
Implications
A.M. Henney
Current Perspectives on Gene and Cell-Based 359(46)
Therapies for Myocardial Protection, Rescue and
Repair
L.G. Melo, A.S. Pachori, D. Kong, V.J. Dzau
Subject Index 405

354040209.TOC3540402098



1 Introduction 1 (4)

2 Model Flow, Wakes and Vortices in High Lift 5 (118)

Configuration

2.1 Experimental Analysis and Modulation of

Vortices

E. ヨzger, I. Schell, D. Jacob 1 (38)

2.2 Simulation of Vortex Sheets at Take-Off and

Landing

I. Schell, E. Ozger, D. Jacob 39 (18)

2.3 Analysis of Wakes and Wake-Jet Interaction

E. Fares, W. Schroder 57 (28)

2.4 Aerodynamic Design of Transonic Adaptive 85 (20)

Airfoils with Natural Transition

A. Meijering, W. Limberg, W. Schroder

2.5 Experiments in a Transonic Shock Tube at

High Mach and Reynolds Numbers

Th. Reichel, M. Zechher, H. Olivier 105(18)

3 Numerical Tools and Approaches for Flow 123(102)

Simulation with Local Adaptivity

3.1 H-Adaptive Multiscale Schemes for the

Compressible Navier Stokes Equations -

Polyhedral Discretization, Data Compression and

Mesh Generation

F. Bramkamp, B. Gottschlich-M ler, M. Hesse, 125(80)

Ph. Lamby, S. M ler, J. Ballmann, K.H.

Brakhage, W. Dahmen

3.2 Automated Gradient Calculation

C.H. Bischof, H.M. B ken, B. Lang, A. Rasch 205(20)

4 Computational and Experimental Aeroelasticity 225

4.1 On Well-Posedness and Modelling for

Nonlinear Aeroelasticity

R. Massjung, J. Hurka, W. Dahmen, J. Ballmann 227(22)

4.2 Concepts for Reduced Structural Models of

Airplane Wings in Aeroelasticity

W. Jung, H.-G. Reimendes 249(26)

4.3 Computational Aeroelasticity with Reduced

Structural Models

G. Britten, C. Braun, M. Hesse, J. Baumann 275(26)

4.4 Approximated Nonlinear Stability Analysis

of the Dynamics of Flexible Aircraft

N. Siepenk ter, W. Kasberg, W. Alles 301(22)

4.5 Analysis of Unsteady Airfoils at Low Speeds

X. Bertr疣, H. Olivier, S. Turek 323(28)

4.6 Experiments on Transonic Aerodynamics about

Elastically Suspended Airfoils

C. Hillenherms, W. Schroder, W. Limberg 351(26)

4.7 Design, Qualification and Experimental

Investigation on Flexible Wind-Tunnel Wing

Models

M. K舂pchen, H. Korsch, A. Dafnis, H.-G. 377

Reimerdes