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Full Description
Comprehensive coverage of sustainable multicomponent reactions across multiple disciplines
Multicomponent reactions (MCRs) enable the combination of three or more starting materials in a single vessel to afford diverse and complex products while aligning with green chemistry principles. Multicomponent Reactions: Applications in Organic Synthesis and Drug Discovery summarizes the most recent MCR applications and emerging trends, providing expert knowledge on current advancements across organic chemistry, medicinal chemistry, polymer and analytical chemistry.
The book explores sustainable chemical approaches, such as electrochemistry, photochemistry, mechanochemistry, and flow chemistry. It also covers biocatalytic MCRs, reactions in non-conventional solvents, isotope labeling, and late-stage functionalization.
Additional topics include:
Artificial intelligence and automated synthesis (HTS) enhancing MCRs workflows in research laboratories
Drug discovery applications demonstrating how MCRs rapidly generate diverse chemical libraries of heterocycles and bioactive compounds, including protein degraders
Reactive intermediates and reaction mechanisms in multicomponent processes
Innovative approaches for designing advanced materials with specific functional properties
MCRs in chemical education
Multicomponent Reactions: Applications in Organic Synthesis and Drug Discovery will benefit organic chemists, medicinal chemists, materials scientists, and chemical engineers, providing them with practical knowledge of sustainable synthetic methods from expert contributors across various research fields.
Contents
Preface xi
1 Multicomponent Reactions for a Sustainable Organic Synthesis 1
Elena Cassera, Davide Ravelli, Mariateresa Giustiniano, and Maurizio Fagnoni
2 Light-triggered Multicomponent Reactions 33
Lorenzo Di Terlizzi and Stefano Protti
3 Multicomponent Electrochemical Strategies for Modern Organic Synthesis 55
Rajesh Kumar, Vinay Thatikonda, and Upendra K. Sharma
4 Mechanochemical Multicomponent Reactions 79
Francesco Basoccu, Dipak J. Fartade, and Andrea Porcheddu
5 The Use of Microwave-assisted Multicomponent Reactions for the Synthesis of Heterocycles Containing Isatin or Organophosphorus Moiety 119
Dániel Steinsits and Erika Bálint
6 Biocatalytic Multicomponent Reactions 141
Camilla Russo, Flora Antoniou, and Daniele Castagnolo
7 Isocyanide-based Multicomponent Reactions in Aqueous Media 185
Mohammad Taghi Nazeri, Tahereh Nasiriani, Nuhaa Shaheed, and Ahmad Shaabani
8 Non-isocyanide-based Multicomponent Reactions in Aqueous Media 243
Mohammad Taghi Nazeri, Tahereh Nasiriani, Nuhaa Shaheed, and Ahmad Shaabani
9 The Use of Nonconventional Solvents in Multicomponent Reactions 301
Yavar Ahmadi and Ali Ramazani
10 Nanoreactors Technology in Multicomponent Reactions 325
Seyedmohammad Hosseininezhad, Melika Seydi, and Ali Ramazani
11 Multicomponent Reactions in Automated Synthetic Chemistry 375
Imma Capriello and Alexander Domling
12 Scale-up and Automation of Multicomponent Reactions via Continuous Flow 405
Johannes Bingold, Andreas Brunschweiger, and Norbert Kockmann
13 Investigating Multicomponent Reactions Mechanisms 435
Brenno A. D. Neto, Giovanni W. Amarante, and Alexandre A. M. Lapis
14 Reactive Intermediates in Isocyanide-based Multicomponent Reactions 457
Ana G. Neo and Carlos F. Marcos
15 Heterocycle-based Multicomponent Reactions 489
Pau Nadal-Rodríguez, Ouldouz Ghashghaei, and Rodolfo Lavilla
16 Multicomponent Synthesis of Functional Chromophores 513
Larissa Brandner and Thomas J. J. Müller
17 Atropisomers and Molecular Balances via Multicomponent Reactions 543
Michael Fragkiadakis, Michael Kapsalis, and Constantinos Neochoritis
18 Multicomponent Synthesis of Organoselenium Compounds 565
Paola S. Hellwig, Thiago A. Ribeiro, Mateus W. Rambo, Kethelyn M. Rosa, Nicole M. N. Washio, Ricardo F. Schumacher, Eder J. Lenardão, and Filipe Penteado
19 Multicomponent Reactions in Isotope Labeling 613
Kevin Schofield, Aidan McMahon, Vishal Kaleeswaran, Sean Ginn, and Christopher Hulme
20 Harnessing Multicomponent Reactions for the Functionalization of Drugs and Bioactive Natural Products via Innate Reactivity 637
Hélène Beucher and Tatiana Besset
21 Multicomponent Reactions for the Synthesis of Protein Degraders 659
Laura Gioiello, Tracey Pirali and Rita Maria Concetta Di Martino
22 Synthesis of Natural Compounds via Multicomponent Reactions 689
Ana Barbero-Moreno, Miriam Ruiz, and J. Carlos Menéndez
23 Multicomponent Reactions in the Total Synthesis of Biologically Active Natural Products- Part I: Reactions Based on the Use of Isocyanides, Transition Metal Catalysis, and Tandem Conjugate Addition/Electrophilic Enolate Trapping on α , β -Unsaturated Carbonyls 711
Enrique L. Larghi, Andrea B. J. Bracca, Sebastián O. Simonetti, and Teodoro S. Kaufman
24 Multicomponent Reactions in the Total Synthesis of Biologically Active Natural Products- Part II: MCRs Initiated by Nucleophilic Addition to Carbonyl Compounds, Mannich and Related Reactions, Anion Relay Chemistry, [4+2]-Cycloadditions and Other Transformations 741
Enrique L. Larghi, Andrea B. J. Bracca, Sebastián O. Simonetti, and Teodoro S. Kaufman
25 Multicomponent Reactions in Polymer Chemistry 767
Siamak Javanbakht, Reza Mohammadi, and Ahmad Shaabani
26 Multicomponent Derivatization for Advanced Gas and Liquid Chromatographic Methods 785
Serban C. Moldoveanu and Victor David
27 Multicomponent Reactions in Chemical Education 809
Cristina Martini and Andrea Basso
Index 831
