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Full Description
An expertly curated collection of up-to-date resources covering metalloenzyme-targeting drug discovery
Drug Discovery Targeting Metalloenzymes: Strategies and Applications (2 Volume Set) is an extensive collection of papers discussing the latest developments in the field of metalloenzyme-targeting drug discovery. The editor has curated some of the most cutting-edge explorations of metalloenzymes and the drug discovery applications animating discussion in the area today. The included resources examine informatics, tools, computational modeling advancements, high-throughput virtual screening techniques, and other practical, boundary-pushing topics.
This curated compilation of resources explores the challenges associated with developing drugs that specifically target metalloenzymes, as well as the strategies professionals use to overcome them. It includes illustrative case studies that showcase successful drug discovery efforts, examinations of emerging trends in metalloenzyme-targeted therapies in the field of precision medicine, and experimental approaches to the study and discovery of drugs in this area.
Inside the book:
Thorough introductions to metalloenzyme informatics and drug design
Comprehensive explorations of viral metalloenzyme-targeting drug discovery
Practical discussions of autotaxin targeting for therapeutic intervention
Complete treatments of substrate and inhibitor discovery of human glutaminyl cyclases
Perfect for pharmaceutical chemists, biochemists, theoretical chemists, and medicinal chemists, the papers contained in the two volumes of Drug Discovery Targeting Metalloenzymes: Strategies and Applications will also benefit pharmaceutical engineers, biologists, and professionals in the pharmaceutical industry.
Contents
Volume 1
Preface xiii
1 Metalloenzyme Informatics and Drug Design 1
Jun-Lin Yu, Xiao-Tian Huang, Dao-Xing Chen, Cong Zhou, Yao-Gen Wang, and Guo-Bo li
2 Metal-Binding Pharmacophores in Metalloenzyme Drug Discovery 25
Lilia M. Baldauf, Emily A. Podd, and Seth M. Cohen
3 Modeling Metalloenzyme Catalytic Mechanisms by QM/MM Calculations 61
Zhe Li and Ruibo Wu
4 Experimental Strategies in Metalloenzyme Mechanism Study and Drug Discovery 119
Si-Qi Wei, Zi-Yang Chen, and Guo-Bo li
5 Targeting Metalloenzymes by Metallo-Drugs 151
Cheng Chen, Kewu Yang, Hongyan Li, and Hongzhe Sun
6 Targeting Metallo-β-Lactamases to Combat Antibiotic Resistance 171
Mitchell A. Jeffs, Montserrat Mora-Ochomogo, Laila Masalha, Dylan W. Zhao, and Christopher T. Lohans
7 Targeting Disease-Linked Metalloenzymes Involved in RNA Metabolism 213
Simranjeet Kaur and Wei Shen Aik
8 Cyclic Nucleotide Phosphodiesterases: Important Therapeutic Targets 269
Deyan Wu, Shuheng Huang, and Hai-Bin Luo
9 HDAC: A Rising Star in Cancer Therapy 291
Tao Liang, Hao Fang, and Xuben Hou
Volume 2
Preface xiii
10 Drug Discovery Targeting Viral Metalloenzymes 327
Baohu Li, Hui Xu, Jiahui Zhou, Kai Tang, Xinyong Liu, Jinfei Yang, and Peng Zhan
11 Drug Discovery Targeting Carbonic Anhydrase 371
Weina Zhong, Xueying Li, Wenli Zhang, and Wukun Liu
12 Targeting Autotaxin for Therapeutic Intervention 395
Yangyang Chen, Maolin Duan, Jifa Zhang, and Liang Ouyang
13 Targeting ENPP1 for Therapeutic Intervention 425
Yuyan Han, Yaoliang Sun, and Shilin Xu
14 Drug Discovery Targeting Oxygen-Sensing Hypoxia-Inducible Factor Prolyl Hydroxylases 475
YueWuandXiaojinZhang
15 Hijacking Histone Demethylase KDM5B for Novel Therapeutics 507
Wen-Long Wang, Guan-Jun Yang, and Bin Yu
16 Advances and Future Directions in Small-Molecule LpxC Inhibitors Targeting Gram-Negative Bacteria 535
Yue Liu and You-Cai Xiao
17 Substrate and Inhibitor Discovery of Human Glutaminyl Cyclases 563
Jun Mou, Xiang-Min Dong, Jing-Wei Wu, ling-ling Yang, and Guo-Bo li
18 Drug Discovery Targeting Tryptophan/Indoleamine 2,3-Dioxygenase 591
Xiang-li Ning, lin Ma, and Guo-Bo li
Index 643
