大庭誠・出水庸介（共）編／膜透過性ペプチド：設計・開発・応用<br>Cell-Penetrating Peptides : Design, Development and Applications （1. Auflage. 2023. 416 S. 1 Farbabb. 244 mm）

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大庭誠・出水庸介（共）編／膜透過性ペプチド：設計・開発・応用
Cell-Penetrating Peptides : Design, Development and Applications （1. Auflage. 2023. 416 S. 1 Farbabb. 244 mm）

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  • 製本 Hardcover:ハードカバー版／ページ数 416 p.
  • 言語 ENG
  • 商品コード 9783527350117

Full Description

Cell-Penetrating Peptides The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs.

In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell.

Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture.

Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles
Presents the chemical and biological characteristics of CPP action in vitro and in vivo
Describes the structure and design principles of both synthetic and naturally occurring CPPs
Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials

Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.

Contents

Introduction

PART 1: DESGIN OF CPPS
Classification
Tat
Penetration
Guanidino transporter
Arg-rich peptides
Transportan
Hydrophobic peptides
Foldamers

PART 2: MECHANISM OF CPPS
Peptide structure
Cellular uptake
Endosomal escape
Pharmacokinetics

PART 3: DELIVERY TOOLS
Drug delivery
Peptide & protein delivery
Nucleic acid delivery
Polymeric micelles
Lipid-based nanoparticles

PART 4: APPLICATIONS
Oral delivery
Intranasal delivery
Clinical trials
CPPs in Plants