Ligand Binding : Diversity of Modes and Functions (Methods & Principles in Medicinal Chemistry)

Ligand Binding : Diversity of Modes and Functions (Methods & Principles in Medicinal Chemistry)

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  • 製本 Hardcover:ハードカバー版／ページ数 480 p.
  • 言語 ENG
  • 商品コード 9783527338023

Full Description

A practice-oriented overview of ligand binding modes for medicinal chemists, this handbook systematically surveys classical and non-classical binders and their mechanisms for the most relevant drug target classes, including enzyme, receptors and channels.

Contents

PART I: INTRODUCTION
Basic principles of enzymology
Basic principles of receptor pharmacology
Pharmacological advantages/disadvantages of different interaction modes
Capturing inactive conformations
Suppression of transient conformations
Databases of allosteric protein sites

PART II: RECEPTORS
Ion Channels
GPCRs
mGluRs
Other receptor types

PART III: ENZYMES
Allosteric inhibition: Caspases, secretases, kinases
Covalent reversible inhibitors: proteases, kinases
Covalent irreversible inhibitors: historical and recent examples
Interfacial inhibitors
Enzyme Activators

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