Full Description
This three-volume handbook is the standard reference in the field, unparalleled in its comprehensiveness. It covers every conceivable topic related to the expanding and increasingly important field of ion chromatography. The fourth edition is completely updated and revised to include the latest developments in the instrumentation, now stretching to three volumes to reflect the current state of applications.
Ion chromatography is one of the most widely used separation techniques of analytical chemistry with applications in fields such as medicinal chemistry, water chemistry and materials science. Consequently, the number of users of this method is continuously growing, underlining the need for an up-to-date reference.
A true pioneer of this method, Joachim Weiss studied chemistry at the Technical University of Berlin (Germany), where he also received his PhD degree in Analytical Chemistry. In 2002, he did his habilitation in Analytical Chemistry at the Leopold-Franzens University in Innsbruck (Austria), where he is also teaching liquid chromatography. Since 1982, Dr. Weiss has worked at Dionex (now being part of Thermo Fisher Scientific), where he currently holds the position of Technical Director for Dionex Products within the Chromatography and Mass Spectrometry Division (CMD) of Thermo Fisher Scientific, located in Dreieich (Germany).
Contents
Foreword
Preface to the Fourth Edition
1 INTRODUCTION
1.1 Historical Perspective
1.2 Types of Ion Chromatography
1.3 The Ion Chromatographic System
1.4 Advantages of Ion Chromatography
1.5 Selection of Separation and Detection Systems
2 THEORY OF CHROMATOGRAPHY
2.1 Chromatographic Terms
2.2 Parameters for Assessing the Quality of a Separation
2.3 Column Efficiency
2.4 The Concept of Theoretical Plates (van Deemter Theory)
2.5 Van Deemter Curves in Ion Chromatography
3 ANION-EXCHANGE CHROMATOGRAPHY (HPIC)
3.1 General Remarks
3.2 The Ion-Exchange Process
3.3 Thermodynamic Aspects
3.4 Stationary Phases
3.5 Eluents for Anion-Exchange Chromatography
3.6 Suppressor Systems in Anion-Exchange Chromatography
3.7 Anion-Exchange Chromatography of Inorganic Anions
3.8 Anion-Exchange Chromatography of Organic Anions
3.9 Gradient Elution Techniques in Anion-Exchange Chromatography of Inorganic and Organic Anions
3.10 Carbohydrates
3.11 Amino Acids
3.12 Anion-Exchange Chromatography of Proteins
3.13 Nucleic Acids
4 CATION-EXCHANGE CHROMATOGRAPHY (HPIC)
4.1 Stationary Phases
4.2 Eluents in Cation-Exchange Chromatography
4.3 Suppressor Systems in Cation-Exchange Chromatography
4.4 Cation-Exchange Chromatography of Alkali Metals, Alkaline-Earth Metals, and Amines
4.5 Transition Metal Analysis
4.6 Analysis of Polyamines
4.7 Gradient Techniques in Cation-Exchange Chromatography of Inorganic and Organic Cations
4.8 Cation-Exchange Chromatography of Proteins
5 ION-EXCLUSION CHROMATOGRAPHY (HPICE)
5.1 The Ion-Exclusion Process
5.2 Stationary Phases
5.3 Eluents for Ion-Exclusion Chromatography
5.4 Suppressor Systems in Ion-Exclusion Chromatography
5.5 Analysis of Inorganic Acids
5.6 Analysis of Organic Acids
5.7 HPICE/HPIC-Coupling
5.8 Analysis of Alcohols and Aldehydes
5.9 Amino Acids Analysis
5.10 Size-Exclusion Chromatography of Proteins
6 ION-PAIR CHROMATOGRAPHY (MPIC)
6.1 Survey of Existing Retention Models
6.2 Suppressor Systems in Ion-Pair Chromatography
6.3 Experimental Parameters that Affect Retention
6.4 Analysis of Surface-Inactive Ions
6.5 Analysis of Surface-Active Ions
6.6 Applications of the Ion-Suppression Technique
6.7 Applications of Ion Chromatography on Mixed-Mode Stationary Phases
7 HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY (HILIC)
7.1 Separation Mechanism in Hydrophilic Interaction Liquid Chromatography
7.2 Stationary Phases for HILIC
7.3 Factors Affecting Retention in HILIC
7.4 Applications
8 DETECTION METHODS IN ION CHROMATOGRAPHY
8.1 Electrochemical Detection Methods
8.2 Spectrometric Detection Methods
8.3 Aerosol-Based Detection Methods
8.4 Other Detection Methods
8.5 Hyphenated Techniques
9 QUANTITATIVE ANALYSIS
9.1 General
9.2 Analytical Chemical Information Parameters
9.3 Determination of Peak Areas
9.4 Statistical Quantities
9.5 Calibration of an Analytical Method (Basic Calibration)
9.6 Detection Criteria, Limit of Detection, Limit of Determination
9.7 The System of Quality Control Cards
10 APPLICATIONS
10.1 Ion Chromatography in Environmental Analysis
10.2 Ion Chromatography in Power Plant Chemistry
10.3 Ion Chromatography in the Semiconductor Industry
10.4 Ion Chromatography in the Electroplating Industry
10.5 Ion Chromatography in the Detergent and Household Product Industry
10.6 Ion Chromatography in the Food and Beverage Industry
10.7 Ion Chromatography in the Pharmaceutical Industry
10.8 Ion Chromatography in Clinical Chemistry
10.9 Oligosaccharide Analysis of Membrane-Coupled Glycoproteins
10.10 Chemical and Petrochemical Applications
10.11 Other Applications
10.12 Sample Preparation and Matrix Problems
10.13 Concluding Remarks
