Full Description
Covering one of the most important research topics in cancer biology, this is an ideal ready reference for oncologists, cell biologists, pharmaceutists, pathologists, molecular biologists, internists, and researchers working in the pharmaceutical industry.
Following an introduction that provides an overview of tumor angiogenesis, the book goes on to look at mechanisms of angiogenesis and lymphangiogenesis, signal transduction, therapeutic approaches in combination with established treatments, and concludes with a section on imaging and biomarkers in angiogenesis.
Contents
INTRODUCTION
Overview on Tumor Angiogenesis (Donati, Lorenzet)
MECHANISMS OF ANGIOGENESIS AND LYMPHANGIOGENESIS
Molecular Mechanisms of Angiogenesis (Dudley, Claesson-Welsh)
Pro-angiogenic Factors (Ribatti)
The Role of Accessory Cells in Tumor Angiogenesis (Takakura)
Comparison between Developmental and Tumor Angiogenesis (Bikfalvi)
Tumor Lymphangiogenesis (Ramu, Hong)
SIGNAL TRANSDUCTION AND ANGIOGENESIS
Integrin Involvement in Angiogenesis (Akalu, Contois, Brooks)
Signaling Pathways in Tumor Angiogenesis (Abrahams, Daly, Eichten, Li, Noguera-Troise, Thurston)
THERAPEUTIC APPROACHES AND ANGIOGENESIS
Development of an Integrin Targeted Anti-Angiogenic Agent (Swenson, Minea, Markland)
Anti-VEGF Approaches and Newer Antiangiogenic Agents (including combrestatins) which are already in Clinical (Libutti)
Combination of Antiagiogenic Therapy with Other Anticancer Therapies (Gasparini)
Tumor specificity of anti-angiogenic agents (Rixe, Kelly, Giaccone)
IMAGING AND BIOMARKERS IN ANGIOGENESIS
In vivo imaging of tumor angiogenesis (Turkbey, Ravizzini, Choyke)
Identifying Biomarkers to Establish Drug Efficacy (Platero)
