Full Description
Thoroughly updated, incorporating around 25 % new material, Sewald/Jakubke remains the only modern and scientifically up-to-date advanced textbook on peptide biochemistry, distilling the knowledge of hundreds of publications into a highly readable synopsis of this diverse field.
The authors explain the broad fundamentals of peptide synthesis and structure, systematically addressing important families of biologically active peptides, and adopting an interdisciplinary approach that covers application areas in biotechnology, pharmaceutical science, and biomedicine. One major focus is on such "hot" research topics as pseudopeptides, peptidomimetics, and combinatorial synthesis.
This new edition also features study questions for each learning unit, for easier self-study and classroom teaching.
Contents
INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and Main Conformational Features of the Peptide Bond
Building Blocks, Classification, and Nomenclature
Analysis of the Covalent Structure of Peptides and Proteins
Three-Dimensional Structure
Methods of Structural Analysis
BIOLOGY OF PEPTIDES
Historical Aspects and Biological Functions
Biosynthesis
Selected Biologically Active Peptides
PEPTIDE SYNTHESIS
Principles and Objectives
Protection of Functional Groups
Peptide Bond Formation
Racemization During Synthesis
Solid-Phase Peptide Synthesis (SPPS)
Biochemical Synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and Tactics
Solution Phase Synthesis (SPS)
NEW: Solution Phase/Solid Phase-Hybrid Approaches
Optimized Strategies on Polymeric Support
Chemical Ligation Strategies
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine Peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated Peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, AND PEPTIDOMIMETICS
Peptide Design
Modified Peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and De-Novo Design of Peptides and Proteins
COMBINATORIAL PEPTIDE SYNTHESIS
Parallel Synthesis
Synthesis of Mixtures
APPLICATION OF PEPTIDES AND PROTEINS
NEW: General Production Strategies
NEW: Improvement of the Therapeutic Potential
Protein Pharmaceuticals
Peptide Pharmaceuticals
PEPTIDES IN PROTEOMICS
NEW: Genome and Proteome
NEW: Separation Methods
NEW: Peptide and Protein Analysis in Proteomics
NEW: Activity-Based Proteomics
