- ホーム
- > 洋書
- > ドイツ書
- > Mathematics, Sciences & Technology
- > Chemistry
- > organic chemistry
Full Description
"I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication."
—Victor Snieckus
This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry.
Contents
Foreword VII
Preface XIII
Part 1 Introduction 1
1.1 History of Synthesis 3
1.2 Milestones in Structure Elucidation 23
1.3 Milestones in Organic Synthesis 41
Part 2 Strategy and Tactics 79
2.1 Introduction 81
2.2 Principles and Issues Impacting Synthesis (Strategy) 87
2.3 Principles and Issues Impacting Design - Dimensional Analysis (Strategy) 129
2.4 Principles and Issues of Methods (Tactics) 165
Part 3 Comparative Design: Classics in Terpene Synthesis 205
3.1 Introduction 207
3.2 Juvenile Hormones 217
3.3 Cedrenes 229
3.4 Zizaanes 255
3.5 Hydroazulenes 277
3.6 Vernolepin 341
3.7 Triquinanes 361
3.8 Compactin 431
3.9 Aphidicolin 449
3.10 Miscellaneous Terpenes 469
3.11 Taxol 499
Part 4 Comparative Design: Classics in Alkaloid Synthesis 525
4.1 Introduction 527
4.2 Lycopodium Alkaloids 573
4.3 Daphniphyllum Alkaloids 603
4.4 Pyrrolizidine Alkaloids 617
4.5 Cephalotaxus Alkaloids 655
4.6 Amaryllidaceae Constituents 689
4.7 Morphine 727
4.8 Indole Alkaloids 759
Part 5 Miscellaneous Compounds 843
5.1 Introduction 845
5.2 Palytoxin 891
5.3 Indinavir 909
Part 6 Outlook 917
6.1 Introduction 919
6.2 A Short History of Accomplishments in Synthesis 921
6.3 Factors Influencing the Practice of Organic Synthesis 923
Part 7 Acknowledgments 945
Part 8 Appendix 947
8.1 Abbreviations, Acronyms, and Symbols 949
8.2 Guide to the Literature 953
Subject index 957
Author index 995
Index of personal recollection 1003
