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基本説明
Provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system.
Description
(Short description)
Mit 38 Substanzen und Substanzgruppen behandelt das Buch sämtliche Neurotransmitter sowie die Mehrzahl der Neuromodulatoren. Für jede behandelte neuroaktive Substanz erhält der Leser umfassende Angaben zu Biosynthese, Degradation, Vorkommen im zentralen Nervensystem, Rezeptoren, Signaltransduktionswegen und biologischen Wirkungen. Einführende Kapitel zu den Grundlagen und Methoden machen dieses Buch zu einem wertvollen neurowissenschaftlichen Nachschlagewerk für Forscher, Dozenten und Studenten in den Bereichen Molekularbiologie, Biochemie, Medizin, Pharmakologie und Physiologie.
(Text)
What are the biological effects of neuropeptides and other neuroactive substances? What are their receptors, their pharmaceutical applications? The intensive search for answers to these questions culminated in the 2000 Nobel Prize for Medicine/Physiology being awarded to A. Carlsson, P.Greengard, and E. Kandel for their pioneering research in signal transduction in the nervous system.This handbook gives a short but detailed overview of neuroactive substances, covering all neurotransmitters and most neuromodulators. It provides clear and comprehensive information on their biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system. Introductory chapters on general aspects and on methods for analyzing neuroactive substances make this a valuable tool for researchers, teachers, and advanced students in molecular biology, biochemistry, medicine, neurosciences, pharmacology, and physiology.
(Table of content)
From the Contents:
- INTRODUCTION
Neuroactive Substances
Receptors and Transporters
Distribution and Localization of Neurotransmitters and Neuromodulators
The Blood-Brain Barrier
Volume Transmission and Wiring Transmission
- METHODS FOR STUDYING NEUROACTIVE SUBSTANCES
Bio- and Radioisotope Assays
Microdialysis and Electrochemical Detection
Chromatography
Autoradiography
Immunohistochemical Methods
In-situ Hybridization
Staining and Neuroanatomical Tract Tracing
Electrophysiology
Behavioral Testing
- NEUROTRANSMITTERS
Acetylcholine
Dopamine
GABA (Gamma-Amino Butyric Acid)
Glutamate and Aspartate
Glycine
Histamine
Norepinephrine
Serotonin (5-hydroxytryptamine)
- NEUROMODULATORS
Adrenocorticotropic Hormone (ACTH)
Anandamide
Angiotensin
Atrial Natriuretic Factor
Calcitonin and Calcitonin Gene-Related Protein
Cholecystokinin
Corticotropin-Releasing Factor (CRF)
Dynorphin
Eicosanoids and Arachidonic Acid
Endorphin
Enkephalin
Galanin
Growth Hormone-Releasing Hormone
Gonadotropin-Rel easing Hormone
Interleukin
Melanin-Concentrating Hormone
Melanocyte-Stimulating Hormone
Neurotensin
Nitric Oxide
Nociceptin (Orphanin FQ)
Neuropeptide Y
PACAP (pituitary adenylate cyclase-activating polypeptide)
Proopiomelanocortin
Purines
Somatostatin
Substance P and Tachykinins
Thyrotropin-Releasing Hormone
Tyr-MIF-1 Family
Vasoactive Intestinal Polypeptide (VIP)
Vasopressin and Oxytocin
(Author portrait)
Rolf Dermietzel is Professor and head of the Department of Neuroanatomy and Molecular Brain Research at the Ruhr University in Bochum, Germany. He gained his PhD from the University Hospital in Essen, Germany, in 1970, before training in cell biology at the California Institute of Technology and the Marine Biological Institute in Woods Hole, MA.
