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基本説明
髄膜炎菌性疾患の近年の成果、基礎研究や疫学、あらたな治療方針、臨床管理などを論じるハンドブック。
Contents: Historical Aspects; Epidemiology of Meningococcal Disease; Genetics and Genomics of the Meningococcus; Infection Biology; Development of Vaccines; Clinical and Public Health Management.
Description
(Text)
A comprehensive overview of recent advances, from current basic research and epidemiology, to novel therapeutic strategies andclinical management. Here, the leading scientists who have made major advances in the field provide up-to-date reviews and describe their current knowledge and concepts.
As such, this is the first volume to summarize the implications of the meningococcus genome-sequencing project, emphasizing the novel strategies in vaccine development. Following a look at the history, the authors go on to treat the epidemiology of meningococcal disease, as well as the genetics, structure and function of virulence factors. Further chapters cover cross-talk between meningococci and host cells, genomics and immunobiology.
The result is a standard textbook for all scientists working in the field. While aimed at advanced specialists in basic research, epidemiologists, public health workers, vaccine developers and clinicians, the book is equally appropriate as introductory reading for graduates embarking on their carrier in this field.
(Table of content)
Historical Aspects
EPIDEMIOLOGY OF MENINGOCOCCAL DISEASE
Population Structure of the Meningococcus and Epidemiology of Meningococcal Carriage and Disease
Methods for Typing of Meningococci
Antibiotic Resistance
GENETICS AND GENOMICS OF THE MENINGOCOCCUS
Neisseria Meningitidis Genome Sequencing Projects
Phase Variation and Adaption
Transformation and DNA Repair
Genetics, Structure and Function of Capsule
Genetics, Structure and Function of Lipopolysaccharide
Genetics, Structure and Function of Major Outer Membrane Proteins
Iron Metabolism in Neisseria Meningitidis
Genetics, Structure and Function of Pili
INFECTION BIOLOGY
Mechanisms of Attachment and Invasion
Role of Complement in Defense Against Meningococcal Infection
Immune Responses in Meningococcal Disease
Genetics of Host Response to Meningococcal Infection
DEVELOPMENT OF VACCINES
Surrogates of Protection
Conjugate Vaccines
Outer Membrane Vesicle Based Meningococcal Vaccines
Genome Mining and Reverse Vaccinology
Vaccination for the Control of Meningococcal Disease: The Use of Meningococcal Vaccines from the Public Health Perspective
CLINICAL AND PUBLIC HEALTH MANAGEMENT
Pathogenesis and Pathophysiology of Invasive Meningococcal Disease
Clinical Course of Disease, Treatment and Clinical Management
Public Health Management
