基本説明
国際的専門チームが、プログラム細胞死の原理から、がんの進展におけるアポトーシスの役割や新生の治療戦略を解説しています。
Volume I. Apoptosis signaling - I.1. Death receptor. I.2. Mitochondria. I.3. Effector systems. I.4. Bcl-2 family. I.5. IAPs. I.6. Survival pathways. I.7. Oncogenes/Tumor suppressor genes. I.8. Modulators. I.9. Lysosomes and non-apoptotic pathways. I.10. Phagocytosis/ Clearance. Volume II. Apoptosis in cancer and cancer therapy - II.1. Models systems. II.2. Molecular diagnosis. II.3. Cellular stress, DNA damage & repair. II.4. Molecular targets and therapeutic aspects
Full Description
Here, an international and highly distinguished team of authors leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets, and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.
Contents
VOLUME 1. Preface. PART ICD95/CD95 Ligand Signaling in Apoptosis and Cancer (K. Gulow, et al.). 2. The TRAIL Receptor-Ligand System: Biochemistry of Apoptosis Induction, Therapeutic Potential for Cancer Treatment and Physiological Function (H. Walczak, et al.). 3. Mechanisms of Tumor Necrosis Factor-Induced Cell Death (H. Wajant). 4. Cellular FLICE-inhibitory Protein: An Update (O. Micheau). 5. Dependence Receptors and Apoptosis (P. Mehlen & F. Lourenco). PART II: MITOCHONDRIA. 6. Role of Mitochondrial Proteins in Apoptosis (X. Saelens, et al.). 7. Omi/HtrA2: A Mitochondrial Serine Protease Regulating Cellular Life and Death (Y. Suzuki & R. Takahashi). 8. Apoptosis-inducing Factor (N. Vahsen & G. Kroemer). PART III: EFFECTOR SYSTEMS. 9. Caspases: Agents of Defense and Destruction (C. Adrain & S. Martin). 10. The Role of the Apoptosome in Apoptosis and Cancer Therapy (K. Cain). PART IV: BcL-2 FAMILY. 11. The Role of the Bcl-2 Protein Family in Tumorigenesis and Cancer Therapy (E. Naik & A. strasser). 12. Bax, Bak and Bid: Key Mediators of Apoptosis (C. Dempsey, et al.). 13. The BH3-only Proteins Puma and Noxa: Two Brothers in Arms (M. Erlacher, et al.). PART V: IAPs. 14. Inhibitor of Apoptosis Proteins (M. Holcik). 15. Targeting the Survivin Pathway for Rational Cancer Therapy (D. Altieri). PART VI: SURVIVAL PATHWAYS. 16. Nuclear Factor-kB in Apoptosis and Tumorigenesis (F. Greten & M. Karin). 17. Cell Survival Signaling through Phosphoinositide 3-kinase and Protein Kinase B (M. Scheid & J. Woodgett). 18. Survival Regulation by Ras and Raf (H. Drexler, et al.). PART VII: ONCOGENES/TUMOR SUPPRESSOR GENES. 19. p53-mediated Apoptosis: A Multifaceted Story (D. Speidel & W. Deppert). 20. p73 Affects Cell Fate and Tumorigenesis (S. Ramamdan, et al.). 21. RB and Cancer (B. Chau, et al.). PART VIII: MODULATORS. 22. Calcium Signaling in Apoptosis (S. Orrenius & B. Zhivotovsky). PART IX: LYSOSOMES AND NONAPOPTOTIC PATHWAYS. 23. Lysosomes and Nonapoptotic Pathways (T. Kirkegaard-Sorensen, et al.). PART X: PHAGOCTOSIS/CLEARANCE. 24. The Role of "Eat Me", "Don't Eat Me" and "Find Me" Signals for the Efficient Removal of Apoptotic Cells (K. Lauber & S. Wesselborg). 25. Apoptotic Cell Clearance by Macrophages: Relevance to Tumor Pathogenesis (C. Gregory & A. Devitt). VOLUME 2. PART XI: MODEL SYSYTEMS. 26. Mouse Models in Cancer Research (S. Lee & C. Schmitt). PART XII: MOLECULAR DIAGNOSIS. 27. Molecular Imaging in Cancer (M. Bhojani, et al.). 28. Microarray-based Expresson Profiling: From Technological Basics to Diagnostic Perspectives (Y. Syagailo, et al.). PART XIII: CELLULAR STRESS, DNA DAMAGE AND REPAIR. 29. Life and Death Decisions in Response to Stress (M. Pinkoski). 30. Hypoxia in Cancer (E. Hammond, et al.). 31. Apoptosis Induced by DNA-damaging Agents (B. Kaina & W. Roos). 32. DNA Repair (M. Schrauder & L. Wiesmuller). PART XIV: MOLECULAR TARGETS AND THERAPEUTICS. 33. Therapeutic Modulation of Apoptosis in Cancer Therapy (S. Fulda & K. Debatin). 34. Current Therapeutic Strategies Targetging Caspases in Disease (U. Fischer & K. Schulze-Osthoff). 35. Cancer Therapy by Reactivation of the p53 Apoptosis Pathway (H. Stridh, et al.). 36. Small-molecule Inhibitors of the Apoptosis Proteins (R. Armstrong, et al.). 37. Inhibition of the Molecular Chaperone Heat Shock Protein 90 in Cancer: Consequences for the Regulation of Survival Signaling and Induction of Cell Death (P. Clarke, et al.). 38. Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway (C. Granville, et al.). 39. Cermide Signaling in Apoptosis and Cancer Therapy (S. Kullmann, et al.). 40. Histone Deacetylase Inhibitors: Development as Anticancer Agents (P. Marks). 41. Exploiting Apoptosis Pathways for Glioblastoma Therapy (J. Rieger & M. Weller). 42. Radiation Therapy and Apoptosis (V. Jendrossek & C. Belka). 43. Tumor Angiogenesis (J. Becker, et al.). Index.
