Full Description
Edited by one of the leading experts in the field, this handbook emphasizes why solid-state issues are important, which approaches should be taken to avoid problems and exploit the opportunities offered by solid state properties in the pharmaceutical and agricultural industries. With its practical approach, this is at once a guideline for development chemists just entering the field as well as a high-quality source of reference material for specialists in the pharmaceutical and chemical industry, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent departments.
Contents
Preface. List of Contributors. 1. Relevance of Solid-state Properties for Pharmaceutical Products (R. Hilfiker, et al.). 2. Thermodynamics of Polymorphs (S. Lohani & D. Grant). 3. Characterization of Polymorphic Systems Using Thermal Analysis (.D. Craig). 4. Solid-State N MR Spectroscopy (J. Lubach & E. Munson). 5. Vibrational Spectroscopic Methods in Pharmaceutical Solid-State Characterization (J. Chalmers & G. Dent). 6. Crystallography for Polymorphs (P. Ochsenbein & K. Schenk). 7. Light Microscopy (G. Nichols). 8. The Importance of Solvates (U. Griesser). 9. Physical Characterization Hygroscopicity in Pharmaceutical Solids (S. Reutzel-Eden & A. Newman). 10. The Amorphous State (S. Petit & G. Coquerel). 11. Approaches to Polymorphism Screening (R. Hilfiker, et al.). 12. Salt Selection (P. Stahl & B. Sutter). 13. Processing-induced Phase Transformations and Their Implications on Pharmaceutical Product Quality (R. Govindarajan & R. Suryanarayanan). 14. Polymorphism and Patents from a Chemist's Point of View (J. Bernstein). 15. Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications (S. Miller, et al.). Subject Index.
