Full Description
This work is a review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: the structure, regulation and expression of the AP genes; the three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes; the phenotypic abnormalities of the different AP knockout mice; and our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.
Contents
PART IExpression 3 Gene Regulation 4 Protein Structure and Functional Domains 5 Enzymatic Properties 6 Epitope Maps PART II: IN VIVO FUNCTIONS 7 The In Vivo Role of TNAP 8 Knockout Mouse Models PART III: AP EXPRESSION IN HEALTH AND DISEASE 9 APs as Physiological and Disease Markers 10 Neoplastic Expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP Applications of Recombinant APs 12 Use of APs in Prodrug Converting Strategies 13 APs as Therapeutic Agents 14 APs in the Food Industry 15 Veterinary Uses of AP Determinations 16 Methodologies
