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Full Description
With this new book, the authors provide both an introduction to the techniques and strategies for separation, detection, and characterization of proteins as well as an overview of current and emerging applications of proteomics. The result is a concise introduction, complementing other, more advanced or specialized titles. Essential information for postgraduate students and practitioners entering the field.
Contents
INTRODUCTION; o The role of proteomics in meeting the post-genome challenge (Pennington & Dunn); PROTEOMICS; o Bridging genomics & proteomics (Cahill et al.); o Methods for measurement of gene expression (Blakemore); o Sample preparation (Rabilloud); o Two-dimensional polyacrylamide gel electrophoresis for proteome analysis (Dunn & Gorg); o Mass spectrometry-based methods for protein identification and phosphorylation site analysis (Patterson, Aebersold & Goodlet); o The automation of proteomics: technical and informatic solutions for high-throughput protein analysis (Wilkins); o Enhancing high-throughput proteome analysis: the impact of stable isotope labeling (James); o Novel approaches to protein expression analysis (Pennington & Jenkins); o Detecting proteins in polyacrylamide gels and on electroblot membranes (Patton); o Image analysis of two-dimensional gels (Guang-Zhong Yang and Andrew Dowsey); o Glycobiology and proteomics (Packer & Keating); o Protein arrays (Joos, Tomlinson); o Integrating transcriptomics and proteomics (N.N.); o Proteomics databases (Rolf Apweiler); o Phage antibodies as tools for proteomics (Johnson); o Activity profiling (Cravatt); APPLICATIONS; o Application of proteome analysis to drug development and toxicology (Evers & Gray); o Application of proteome analysis to drug development and toxicology (Cutler, Blackstock); o Clinical applications - plasma proteomics (Hochstrasser/Anderson); o Further glycobiology (Rudd); o Cancer (Liotta, Banks, Hanash, Celis); o Heart disease (Dunn, Van Eyck); o Neurodegenerative diseases; o Inflammatory diseases; o 3D proteomics (Hanno Langen)
