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基本説明
Offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates.
Full Description
The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub--unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.
Contents
Colour Plates.PART I.1. Challenges for the Vaccine Developer, including Correlates of Protection (G. Nossal). PART II: VACCINATION AND IMMUNE RESPONSE.2. Shaping Adaptive Immunity against Pathogens: The Contribution of Innate Immune Responses (S. Ehlers & S. Bulfone-Paus).3. Adjuvant-induced Th2- and Th1 -dominated Immune Responses in Vaccination (J. Brewer & K. Pollock).4. Memory (A. Ploss & E. Pamer).5. T-Cell based Vaccines (K. Huster, et al.). PART III: ADJUVANTS.6. Microbial Adjuvants (K. Heeg, et al.). 7. Host-derived Adjuvants (N. Hilf, et al.). 8. Microparticles as Vaccine Adjuvants and Delivery Systems (D. O'Hagan & M. Singh).9. Liposomes and ISCOMs (G. Kersten, et al.). 10. Virosomal Technology and Mucosal Adjuvants (J. Viret, et al.). PART IV: CLASSICAL AND NOVEL VACCINATION STRATEGIES: A COMPARISON.11. Classical Bacterial Vaccines (T. Ebensen, et al.). 12. Subunit Vaccines and Toxoids (M. Lattanzi, et al.). 13. Engineering Virus Vectors for Subunit Vaccines (J. Nkolola & T. Hanke).14. Update on Antiviral DNA Vaccine Research (2000-2003) (D. Franke, et al.).15. Live Recombinant Bacterial Vaccines (S. Clare & G. Dougan).16. Mucosal Vaccination (W. Olszewska & P. Openshaw).17. Passive Vaccination and Antidotes: A Novel Strategy for Generation of Wide-spectrum Protective Antibodies (A. Cassone & L. Polonelli).18. Plant-based Oral Vaccines (K. Wang, et al.). 19. Virus-like Particles: Combining Innate and Adaptive Immunity for Effective Vaccination (M. Bachmann & G. Jennings). PART V: VACCINES FOR SPECIFIC TARGETS.20. Helicobacter Pylori (P. Ruggiero, et al.). 21. Novel Vaccination Strategies against Tuberculosis (S. Kaufmann).22. Rationale for Malaria Vaccine Development (A. Saul, et al.).23. Vaccine for Specific Targets: HIV (R. Kay, et al.). 24. Vaccines against Bioterror Agents (K. Elkins, et al.). PART VI: VACCINES IN THE REAL WORLD: SAFETY, COST EFFICIENCY AND IMPACT OF VACCINATION.25. Imperfect Vaccines and the Evolution of Pathogen Virulence (P. Ewald).26. Cost-Effectiveness of Vaccinations (T. Szucs).27. Immunological Safety of Vaccines: Facts, Hypothesis and Allegations (M. Goldman & P. Lambert). Index.
