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Full Description
This second edition of the book on Store-operated Ca2+ Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+ signaling core complex is described which adds to a new understanding of the molecular interactions involved. Each chapter has been revised and extended. The book retains its interdisciplinary approach and supplies biochemists, cell biologists and biophysicists as well as clinicians in immunology, neurology and cardiology with valuable information on Ca2+ signaling mechanisms, functions, dysfunctions and their consequences.
Contents
Part 1. SOCE - Fundamental Mechanistic Concepts.- 1. Introduction.- 2. STIM/Orai Structures: Isolated and in Complex.- 3. Orai, the Pore-Forming Subunit of the CRAC Channel.- 4. The Interactions between STIM and Orai.- 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2+ Entry.- 6. Regulation of STIM and Orai by Thiol Modifications.- 7. Light-operated Ca2+ entry Through Engineered CRAC Channels.- 8. Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes.- 9. Contribution of TRPC1 in Store-operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function.- 10. Auxiliary Proteins of the STIM/Orai Complex.- Part 2.SOCE - Crosstalk between Organelle and Cellular Compartments.- 11. Introduction.- 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE.- 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores.- 14. The Role of Mitochondria in the Activation/Maintenance of SOCE Store-operated Ca2+Entry and Mitochondria.- 15. The Role of Mitochondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2+ Entry.- 16.The Role of Mitochondria in the Activation/Maintenance of SOCE - The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility and Location to Store-operated Ca2+ Entry.- 17.Tissue specificity - The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling.- 18. Tissue specificity SOCE - Implications for Ca2+ Handling in Endothelial Cells.- 19. Tissue specificity - Store-operated Ca2+ Entry in Cardiac Myocytes.- Part 3. SOCE - Molecular and Cellular (Patho) Physiology.- 20. Introduction.- 21. Immunological Disorders - Regulation of Ca2+ Signaling in T Lymphocytes.- 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders.- 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2+ Handling in Platelet Dysfunction.- 24. Cardiovascular and Hemostatic Discorders - SOCE in Cardiovascular Cells - Emerging Targets for Therapeutic Intervention.- 25. Cardiac Remodelling and Disease - SOCE and TRPC Signaling in Cardiac Pathology.- 26. Cardiac Remodelling and Disease - Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology.- 27. Neurological and Motor Disorders - Neuronal Store-operated Ca2+ Signaling: An Overview and its Function.- 28. Neurological and Motor Disorders - TRPC in Skeletal Muscle.- 29. Fertility - Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation.- 30. Metabolic Disorders and Cancer - Hepatocyte Store-operated Ca2+ Channels in Non-alcoholic Fatty Liver Disease.- 31. Metabolic Disorders and Cancer - Store-operated Ca2+ Entry in Cancer: Focus on IP3R-mediated Ca2+ Release from Intracellular Stores and its Role in Migration and Invasion.
