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Full Description
This book presents a general introduction to and review of HIV-associated hematological malignancies, with a special focus on practical management issues. Each of the relevant malignancies is addressed individually, with an overview of treatment approaches, assessment of evidence regarding their efficacy, and discussion of therapeutic controversies. In addition, careful consideration is paid to issues in molecular and clinical pathology, epidemiological aspects, symptomatology, diagnosis, and risk factors. Separate chapters are devoted to autologous and allogeneic stem cell transplantation and to chemotherapy and interactions with antiretroviral agents. Many of the chapters are written by experts who have been instrumental in shifting the balance for people living with HIV and blood cancers. While two decades ago this diagnosis represented a death sentence, advances in treatment have transformed these cancers into often curable conditions. Nevertheless, optimal treatment of hematological malignancies remains a challenge, particularly in patients with severe immunosuppression. This book will be an invaluable source of information for all practitioners in the fields of clinical hematology and medical oncology and HIV medicine.
Contents
Pathology.- Epidemiology.- Non-Hodgkin Lymphoma.-Hodgkin lymphoma.- Acute Myeloid Leukemia (AML) & Myelodysplastic Syndrome (MDS).- Acute lymphoblastic leukemia (ALL).- Autologous stem cell transplantation.- Allogeneic stem cell transplantation.- Multiple myeloma and monoclonal gammopathy of unknown significance.- Myeloproliferative disorders.- Multicentric Castelman's disease.- Chemotherapy and interactions with combination antiretroviral therapy (cART).- Special considerations.
