Protein Targeting Compounds : Prediction, Selection and Activity of Specific Inhibitors (1st ed. 2015. 2015. viii, 288 S. 18 SW-Abb., 31 Farbabb. 235 mm)

個数:

Protein Targeting Compounds : Prediction, Selection and Activity of Specific Inhibitors (1st ed. 2015. 2015. viii, 288 S. 18 SW-Abb., 31 Farbabb. 235 mm)

  • 在庫がございません。海外の書籍取次会社を通じて出版社等からお取り寄せいたします。
    通常6~9週間ほどで発送の見込みですが、商品によってはさらに時間がかかることもございます。
    重要ご説明事項
    1. 納期遅延や、ご入手不能となる場合がございます。
    2. 複数冊ご注文の場合は、ご注文数量が揃ってからまとめて発送いたします。
    3. 美品のご指定は承りかねます。

    ●3Dセキュア導入とクレジットカードによるお支払いについて
  • 【入荷遅延について】
    世界情勢の影響により、海外からお取り寄せとなる洋書・洋古書の入荷が、表示している標準的な納期よりも遅延する場合がございます。
    おそれいりますが、あらかじめご了承くださいますようお願い申し上げます。
  • ◆画像の表紙や帯等は実物とは異なる場合があります。
  • ◆ウェブストアでの洋書販売価格は、弊社店舗等での販売価格とは異なります。
    また、洋書販売価格は、ご注文確定時点での日本円価格となります。
    ご注文確定後に、同じ洋書の販売価格が変動しても、それは反映されません。
  • 製本 Hardcover:ハードカバー版
  • 言語 ENG
  • 商品コード 9783319224725

Full Description

This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies for ER intrabodies, peptides and aptamers - Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology - Antibodies for cancer therapy and inhibitors of angiogenesis. The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology.
The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.

Contents

Introduction.- Part I Methods of Structure Prediction.- Chapter 1 In Silico Prediction of Target-Inhibitor Interactions.- Part II Antibodies.- Chapter 2 Antibodies and Selection of Monoclonal Antibodies.- Chapter 3 Selection of Recombinant Human Antibodies.- Chapter 4 Selection of Recombinant Human Antibodies against Toxins and Viruses.- Chapter 5 Recent Advances with ER Targeted Intrabodies.- Chapter 6 Therapeutic Blocking Antibodies against Oncogenic Receptors and Growth Factors.- Chapter 7 Synthetic Cystine-Knot Miniproteins-Valuable Scaffolds for Polypeptide Engineering.- Part III Peptides, Small Molecules and Aptamers.- Chapter 8 Peptides and Peptide Analogs to Inhibit Protein.- Chapter 9 Allosteric Modulators of the Class A G Protein coupled Receptors.- Chapter 10 Phosphatases: Their Roles in Cancer and their Chemical Modulators.- Chapter 11 Selection and Application of Aptamers and Intramers.- Part IV Angiogenesis Inhibitors.- Chapter 12 Inhibitors of Angiogenesis.

最近チェックした商品