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Full Description
This thesis describes an investigation into the temperature dependent magnetic hyperthermia (MHT) behavior of Fe3O4 ferrofluids. The ability of magnetic nanoparticles to produce heat in an external oscillating magnetic field can be exploited for cancer therapy and has been the subject of intense research across various branches of science and engineering.The physical and magnetic properties of these nanoparticles were characterized using various experimental techniques and the experimental results were interpreted using the theoretical framework of linear response theory. The thesis describes three significant contributions to the existing body of knowledge on MHT: A technique for thermodynamic modeling of nonadiabatic systems to extract the correct power output by MNPs, the prediction of temperature dependent behavior of MNPs, and the extraction of important material parameters such as anisotropy energy density. These three aspects are of great significance to both laboratory scientists as well as practicing oncologists to properly quantify the performance of nano-composites designed for therapy.
Contents
Introduction and Background.- Superparamagnetism and Magnetic Hyperthermia.- Methods of Synthesis and Characterization of Fe3O4 Ferrofluids.- Temperature Dependent Magnetic Hyperthermia Studies of Dextran Coated Fe3O4 Ferrofluids.- Size Dependent Magnetic Hyperthermia Studies of Dextran Coated Fe3O4 Ferrofluids.- Comparison of Magnetic Hyperthermia in Dextran and PEG Coated Fe3O4 Ferrofluids.- Summary and Future Work.
