Full Description
The term "Translational Research" reflects today's integration of basic research ("bench") findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient ("bedside") to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment.
Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.
Contents
Introduction - What Is Translational Research.- Insights into heart development and regeneration.- Basis Of Cell Excitability And Cardiac Conduction System.- The Renin-Angiotensin-Aldosterone System In Cardiovascular Diseases.- Beta adrenergic receptors.- The hypothalamic-pituitary-adrenal axis in human health and disease.- Genetic Polymorphisms.- Genetic Polymorphisms and the Vascular Endothelium.- The role of microRNAs in Cardiovascular Disease.- Pathways To Myocardial Hypertrophy.- The multiple actions of the insulin-like growth factor-I signaling in the myocardium.- Calcium Cycling Circuits in Cardiac Physiology and Pathophysiology.- Inflammation and atherosclerosis.- Stress proteins and the Adaptive Response of the Heart.- The Mechanisms And Modalities Of Cell Death.- Repair of the infarcted myocardium.- Pathways to cardiac remodeling.- A Translational Approach to Probe the Arrhythmic Potential of the Heart: Therapeutic Considerations.- Animal Models Of Cardiovascular Disease.- Experimental in vitro assessment of cardiac function.- In vivo experimental assessment of cardiac function.- Non invasive imaging modalities for Cardiovascular Translational Research- Technical Considerations.- Cardiovascular Applications of Non-Invasive Imaging in Cardiovascular Diseases: from Bench to Bedside.- Molecular Imaging of Inflammation Using Echoardiography: Advances With the Use of Microbubbles.- Clinical Aspects And Genetics Of Cardiomyopathies.- Cardiorenal Syndrome: What Basic Research Can Contribute.- Clinical aspects of Cardiorenal Syndrome: consequences of therapy with the Renin-Angiotensin System Inhibitors.- Pre-, Peri-, and Post-Conditioning the ischemic myocardium: Challenges, Confounders and Expectations.- Gene Therapy for the Heart.- Cell therapy in cardiac diseases.- Moving Towards a Novel Paradigm in Drug Development for Worsening Heart Failure: The T1 Model (Mechanistic Translational Phase).
