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Full Description
Infectious diseases are the second leading cause of death worldwide. Their dynamic nature due to persistent, emerging, and re-emerging infections continues to challenge health care systems around the world. In addition, individuals do not respond equally to infection, and pathogens of the same species are more disparate than once thought. It is incontrovertible that much of this diversity is attributable to genetic variation. Over the past two decades, genomics has provided remarkable insight into susceptibility, resistance, and progression of infection, yet the gap between genomics research and public health application remains large. This special issue highlights the role of genomics in advancing our understanding of host-pathogen interactions and in improving the quality of mainstay public health tools including genomic epidemiology, diagnostics/screening, and vaccines.
Contents
Genomics Research: The Underpinning of Infectious Disease Prevention and Control Strategies: Malik, S.; Genetic Susceptibility to West Nile Virus and Dengue: Loeb, M.; The Role of Polymorphisms in Host Immune Genes in Determining the Severity of Respiratory Illness Caused by Pandemic H1N1 Influenza: Keynan, Y.; Malik, S.; Fowke, K.R.; The Genetics of Susceptibility to Variant Creutzfeldt-Jakob Disease: Saba, R.; Booth, S.A.; Public Health Genomics and the New Molecular Epidemiology of Bacterial Pathogens: Gilmour, M.W.; Graham, M.; Reimer, A.; Van Domselaar, G.; Recent Advances in Research of HIV Infection: Implications of Viral and Host Genetics on Treatment and Prevention: Haaland, R.E.; Johnson, J.A.; Tang, J.; Malaria Diagnostics and Surveillance in the Post-Genomic Era: Lucchi, N.W.; Oberstaller, J.; Kissinger, J.C.; Udhayakumar, V.; Host Genomics and Control of Tuberculosis Infection: Cobat, A.; Orlova, M.; Barrera, L.F.; Schurr, E.; Chlamydia trachomatis Infections and Subfertility: Opportunities to Translate Host Pathogen Genomic Data into Public Health: Lal, J.A.; Malogajski, J.; Verweij, S.P.; de Boer, P.; Ambrosino, E.; Brand, A.; Ouburg, S.; Morre, S.A.; Deep Sequencing in Pre- and Clinical Vaccine Research: Prachi, P.; Donati, C.; Masciopinto, F.; Rappuoli, R.; Bagnoll, F.; Genomics for Public Health Improvement: Relevant International Ethical and Policy Issues around Genome-Wide Association Studies and Biobanks: Pang, T.; Author and Subject Index.



