Innate Immunity: Resistance and Disease-Promoting Principles (Else Kröner-Fresenius Symposia Vol.4) （2013. 130 S. 13 fig., 10 in color. 26 cm）

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Innate Immunity: Resistance and Disease-Promoting Principles (Else Kröner-Fresenius Symposia Vol.4) （2013. 130 S. 13 fig., 10 in color. 26 cm）

Herausgegeben von Hartmann, G./ Wagner, H./ Pahernik, S.

ウェブストア価格 ¥19,819（本体¥18,018）
KARGER（2013発売）
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ポイント 180pt

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製本 Hardcover:ハードカバー版
商品コード 9783318023473

Full Description

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art' in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

Preface: Pahernik, S.; Introduction: Wagner, H.; Hartmann, G.; Innate Immunity and Inflammation; Innate Immunity, Inflammation and Colorectal Cancer: Wang, K.; Grivennikov, S.; Karin, M.; Immunobiology of C-Type Lectin Receptors: Roth, S.; Thomas, C.; Ruland, J.; Mechanisms of IL-1[beta] Maturation in Neutrophils: Mankan, A.K.; Hornung, V.; Innate Immunity and Transplantation; The Innate Immune System: Its Rediscovery before Toll Was Described: Land, W.G.; Messmer, K.; Innate-Adaptive Immune Responses in Organ Ischemia/Reperfusion Injury: Ji, H.; Zhai, Y.; Kupiec-Weglinski, J.W.; Tolerogenic Dendritic Cells in Transplantation: From Preclinical to Clinical Application: Moreau, A.; Cuturi, M.-C.; Innate Immunity and Intestinal Microbiota; Microbiota's Influence on Immunity: Honda, K.; Tanoue, T.; Nagano, Y.; Atarashi, K.; Inflammasomes and Mucosal Immune Response: Elinav, E.; Henao-Mejia, J.; Flavell, R.A.; Microbial Endocrinology: An Evolution-Based Shared Mechanism Determining Microbiota's Influence on Health and Disease: Lyte, M.; Innate Immunity and Disease Promotion; Standing Guard: Innate Lymphoid Cells Promote Immunity and Tissue Homeostasis at Barrier Surfaces: Monticelli, L.A.; Artis, D.; miRNAs That Shape the Innate Immune System: Regulation through Toll-Like Receptor Signaling: Curtis, A.M.; O'Neill, L.A.J.; Type 2 Diabetes and Islet Inflammation: Donath, M.Y.; The Innate Immune System in Alzheimer's Disease: Beckert, H.; Halle, A.; Role of Inflammasomes in Obesity: Dixit, V.D.; Gut-Brain Communication in the Regulation of System Metabolism: Muller, T.D.; Pfluger, P.T.; Tschop, M.H.; Drosophila and Immunity; Metabolism and Innate Immunity: FOXO Regulation of Antimicrobial Peptides in Drosophila: Loch, G.; Jentgens, E.; Bulow, M.; Zinke, I.; Mori, T.; Suzuki, S.; Takeyama, H.; Hoch, M.; Innate Signaling and Adaptive Immunity; Dendritic Cells Orchestrate Innate Immunity against Bacterial Kidney Infection: Tittel, A.P.; Heuser, C.; Garbi, N.; Kurts, C.; Speakers at the Symposium; Author and Subject Index.