Full Description
Psychoimmunology is a rapidly maturing area of scientific endeavor that provides a compelling integrative link between the immune system and its response to stress and psychiatric illness. Stress initiates pathological changes by activating the immune and endocrine systems. Inflammation is at the core of the complex and interactive systems that both contribute to and result from psychopathology. Consequently, inflammation research advances our knowledge of the pathology of depression, schizophrenia, chronic fatigue syndrome, posttraumatic stress disorder and a host of co-morbid conditions, notably diabetes, cardiovascular disease and cerebrovascular disease. The possible mechanisms underlying the bidirectionality of co-morbid medical and psychiatric disorders can be viewed as a consequence of inflammatory changes. These emerging novel concepts illustrate how the knowledge of inflammation can enable meaningful integration of psychopathology with physical co-morbidity. The innovative articles in this volume highlight the intricate link between psychiatry and psychoimmunology and underscore the central role of inflammation in furthering our understanding of the pathophysiology underlying mental health and illness.
Contents
Basic Aspects of the Immunology of Neuro-inflammation: Wohleb, E.S.; Godbout, J.P.; Stress and Neuroinflammation: Grippo, A.J.; Scotti, M.-A. L.; Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment: Raison, C.L.; Miller, A.H.; Virus Infection as a Cause of Inflammation in Psychiatric Disorders: Bechter, K.; Inflammation, Neurotoxins and Psychiatric Disorders: Myint, A.-M.; Essential Fatty Acids as Potential Anti-Inflammatory Agents in the Treatment of Affective Disorders: Song, C.; The Brain-Gut Axis: A Target for Treating Stress-Related Disorders: Scott, L.V.; Clarke, G.; Dinan, T.G.; The Question of Pro-Inflammatory Immune Activity in Schizophrenia and the Potential Importance of Anti-Inflammatory Drugs: Arolt, V.; Ambree, O.; Inflammation as the Cause of the Metabolic Syndrome in Depression: Leonard, B.E.; Glucocorticoids and Inflammation: A Double-Headed Sword in Depression? How Do Neuro-endocrine and Inflammatory Pathways Interact during Stress to Contribute to the Pathogenesis of Depression? Horowitz, M.A.; Zunszain, P.A.; Anacker, C.; Musaelyan, K.; Pariante, C.M.; Co-Morbidity between Cardiovascular Pathology and Depression: Role of Inflammation: Halaris, A.; Inflammatory and Oxidative and Nitrosative Stress Cascades as New Drug Targets in Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: Maes, M.; Peripheral Inflammation and Cognitive Aging: Lim, A.; Krajina, K.; Marsland, A.L.; Inflammation in Suicidality: Implications for Novel Treatment Options: Janelidze, S.; Brundin, L.
