Blood Platelets - Clinical Relevance （2010）

Gawaz, Meinrad/ In collab. with Boris Bigalke, Suzanne Fatch-Moghadam et al.

Thieme（2010発売）

• 製本 Paperback:紙装版/ペーパーバック版
• 商品コード 9783131462114

Full Description

This book provides a comprehensive survey of the importance of blood platelets for coronary heart diseases. It gives both research workers and clinicians an insight into the function of thrombocytes and the significance of platelets in the clinical framework of coronary heart diseases in order to create an understanding of the differntiated use of antithrombocytic principles. The first part is dedicated to the function of platelets hemostasis and their connections with coagulation cascades. Further sections are devoted to the current methods in the functional diagnostics of thrombocytes.

Contents

1 Antiplatelet Substances 1.2 Acetylsalicylic Acid 1.3 Thienopyridines (Ticlopidine, Clopidogrel, Prasugrel) 1.4 Protease-Activated Receptor (PAR) Antagonists 1.5 Antagonists of the Fibrinogen Receptor 1.6 Synergism 2 Monitoring Antiplatelet Therapy 2.1 Introduction 2.2 Available Methods to Monitor Antiplatelet Drug Response 2.3 Monitoring GPIIb-IIIa Antagonists 2.4 Poor Response to Aspirin and Clopidogrel 2.5 Clinical Relevance of Monitoring Response to Antiplatelet Therapy 2.6 Treatment of Poor Response to Antiplatelet Therapy Guided by Monitoring Drug Effects 2.7 Conclusion 3 Platelet Pharmacogenetics and Pharmacogenomics 3.1 Introduction 3.2 Polymorphic Variants of Platelet Receptors and their Role in Cardiovascular Disease 3.3 Aspirin Pharmacogenomics 3.4 Clopidogrel Pharmacogenomics 3.5 Pharmacogenomics of GPIIb-IIIa Inhibitors 3.6 Conclusions 4 Antiplatelet Therapy in Stable Coronary Artery Disease 4.1 Stable Coronary Artery Disease without Recent Percutaneous Coronary Intervention (PCI) 4.2 Coronary Stent Implantation for Stable Coronary Artery Disease 4.3 Conclusion 5 Antithrombotic Therapy in Acute Coronary Syndrome 5.1 Introduction 5.2 Antiplatelet Therapy 5.3 Anticoagulative Therapy 5.4 Conclusion 6 Antiplatelet Therapy and Drug Eluting Stents 6.1 Late Stent Thrombosis: A Damocles Sword for Patients with DES? 6.2 Bare Metal Stents (BMS) 6.3 Drug Eluting Stents (DES) 6.4 Conclusions 7 Antiplatelet Therapy in Patients at Risk for Thromboembolism 7.1 Risk Stratification in Patients with an Indication for Anticoagulation 7.2 Prevention of Stent Thrombosis 7.3 Prevention of Thromboembolic Events 7.4 Antithrombotic Therapy and Bleeding Complications 7.5 Practical Approach 7.6 Patients at High Risk for Thrombembolic Complications 7.7 Patients at Intermediate Risk for Thrombembolic Complications 7.8 Conclusions 8 Perioperative Management of Patients Requiring Antiplatelet Therapy 8.1 Antiplatelet Therapy for Prevention of Stent Thrombosis 8.2 Urgent Surgery in Patients with Recent Coronary Stent Implantation 8.3 Practical Approach: Treatment Algorithm 8.4 Vital Indication for Surgery in Patients with Dual Antiplatelet Therapy 8.5 Conclusions 9 Drug-Drug Interactions Involving Antiplatelet Agents 9.1 Drug Interactions in Antiplatelet Therapy 9.2 Interaction of Clopidogrel and Statins 9.3 Interaction of Clopidogrel and PPIs 9.4 Interaction of Aspirin and NSAID 9.5 Interaction of Clopidogrel and Calcium Channel Blockers (CCBs) 9.6 Conclusions