Full Description
This new edition provides comprehensive and authoritative coverage of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of Alzheimer's disease. The chapters explore the physiology of polypeptides involved in early-onset and late-onset gene variants, degradation and clearance, and the role of tau. An emerging and exciting theme in the field is the seeding and spreading of toxic, misfolded protein species in the CNS; selected chapters review the nature of these toxic species and the underlying molecular and cellular mechanisms that drive disease pathogenesis. Additional chapters examine the development of organoids to test mechanisms, role of BDNF and neurogenesis in Alzheimer's models, roles of peripheral immune cells, and the microbiome on modulation of Alzheimer's-like pathologies and neuroinflammation. The book also covers what are perhaps the most compelling new findings over the past decade: the identification of genetic variants in genes involved in innate immunity that predispose individuals to late-onset Alzheimer's disease. Also, the new edition covers the data from animal models and humans that have led to the emergence of key biomarkers and clinical trials for Alzheimer's disease that have real promise for changing the course of disease.
Contents
The Role of Peripheral Immunity in Alzheimer's Disease.- Genetics of Alzheimer's Disease.- Apolipoprotein E: Normal Function and Roles in Neurodegenerative Disease.- Microglial Biology in Alzheimer's Disease: From homeostatic functions to maladaptive activation and to therapeutic targeting.- Roles for adult neurogenesis in Alzheimer's Disease.- TREM2: Sustaining Microglial Function and Promoting Neuroprotection in Alzheimer's Disease.- Synucleinopathies and Spreading.- Physiological Roles of the Amyloid Beta Protein.- The Role of the Innate Immune Receptor CD33 in Alzheimer's Disease.- The Prion-Like Molecular Ontogeny of Alzheimer's Disease.- The lymphatic-glymphatic system in Alzheimer's disease.- The contributions of astrocytes to Alzheimer's disease.- Immunotherapy of Alzheimer's Disease.- Microglia and Inflammatory Immune Responses in Alzheimer's Disease.- Mechanisms of Tau Spreading.- MOLECULAR AND CELLULAR FUNCTIONS OF BACE.- Sex-Specific Gut Microbiota in the Pathophysiology of Alzheimer's Disease.- Proteolytic Aβ Degradation: Enzymatic Pathways, Regulatory Mechanisms, and Therapeutic Implications.- Lessons learned from β-secretase inhibitor clinical trials.- Recapitulating Alzheimer's Disease Pathology in Human Neural Cell Culture Models: Challenges and Opportunities.- Regulation γ-Secretase in Alzheimer's Diease.- Biomarkers.- Diverse functions of lysosomes in brain health and Alzheimer's disease.
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