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Description
Since 2022, when the Nobel Prize in Chemistry was jointly awarded to Sharpless, Bertozzi, and Meldal for the development of click chemistry and bioorthogonal chemistry, the field of click chemistry has expanded significantly. For example, it now encompasses new protocols, substrates (including proteins), catalysts, and solvent systems, while conditions have been developed enabling click chemistry to be conducted in a greener and more sustainable manner. In this 2-set volume, we showcase some of the recent advances that have been made with click chemistry by leaders in the field. Volume 1 focuses on click chemistry being used in the synthesis of compounds, which features chapters on novel click chemistry approaches and catalyst systems for the synthesis of various materials, click chemistry in the synthesis of polymers, using click chemistry to immobilize enzymes and catalysts to be used in continuous flow chemistry systems, and the sustainability aspects of click-chemistry transformations. Volume 2 focuses on work done to advance biological applications of click chemistry such as using click chemistry for bioconjugation, peptidomimetics, protein modification in live cells and in vivo, and in the development of PROTACS, as well as for drug delivery. This book will be of interest to practitioners of organic synthesis, bioconjugation and protein modification, continuous flow chemistry, medicinal chemistry (drug delivery), and catalysis (the development of new catalysts).
Click Chemistry for Bioconjugation.- Click Chemistry for Peptidomimetic Applications.- - 2.3. Click chemistry for protein modification in live cells and in vivo.- 2.4. Click Chemistry in the development of PROTACs.- 2.5. Click Chemistry and Drug Delivery.
Ross Jansen-van Vuuren is a Senior Research Associate at the Faculty of Chemistry and Chemical Technology at the University of Ljubljana. He obtained his Ph.D. from the University of Queensland (Brisbane, Australia) with prof. Paul L. Burn in 2012, before completing three postdoctoral research positions (Australia, Canada). In 2021, Ross was awarded a prestigious EUTOPIA Science and Innovation Fellowship developing greener and more sustainable approaches for deuterium incorporation, and in 2023, he received funding from the IIS-ED and the Slovenian Innovation and Research Agency (ARIS) to further support this research, which involves exploring how to use click chemistry to attach (bio)catalysts to surfaces or particles for use in continuous flow chemistry systems.
Janez Ko mrlj is a professor of Organic Chemistry at the Faculty of Chemistry and Chemical Technology, University of Ljubljana. He received his PhD from the University of Ljubljana under Emeritus Professor Slovenko Polanc. His research focuses on developing methods for organic synthesis and investigating reaction mechanisms. Professor Ko mrlj has received the Zois Certificate of Recognition, the highest national recognition conferred to researchers in the Republic of Slovenia, and is a member of the European Academy of Science and Art.
