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Full Description
This book sheds new light on the complex phenomenon of cell fusion, a vital process in various physiological and pathophysiological contexts, including fertilization, placentation, myogenesis, and cancer. While the merging of cells may seem straightforward, it involves a sophisticated interplay of biological mechanisms that are not yet fully understood.
In this new edition, readers will discover insights into the interplay of lipids and peptides in membrane fusion, the role of cell fusion in fertilization and placentation, and the implications of fusion deficiencies in pregnancy diseases. The book also examines the transformation of non-fusogenic cells, such as macrophages and cancer cells, under extrinsic conditions, and the potential link between cell fusion and cancer malignancy through genetic/epigenetic instability. Contributions from leading experts provide a thorough analysis of these topics, inviting readers to explore critical questions about the role of cell fusion in physiology and pathophysiology.
This volume is an essential resource for researchers, scholars, and students in the fields of cell biology, oncology, and virology, offering valuable insights into the mechanisms and implications of cell fusion.
Contents
A Brief Introduction into the Biological Phenomenon of Cell-Cell Fusion.- The interplay of lipids and peptides in Membrane Merger.- Membrane Merger Dynamics in Exocytosis and Endocytosis.- Membrane Fusions During Mammalian Fertilization.- Biophysical Considerations in Cell Fusion.- Trophoblast Fusion Deficiency in Placenta-Related Pregnancy Disorders.- Pathogen-Mediated Cell Fusion and Actin Cytoskeleton.- Cell Fusion in Reprogramming and Regeneration.- How Do Cancer Cells Fuse and Why?.- Polyploidy and Senescence of Cancer Cells - Impact of Cell Fusion.- Cell Fusion-Mediated Induction of Polyploidy, Aneuploidy and Genomic Instability in Cancer Cells.- Genomic Reshuffling After Cell Fusion - Catalyst for Cancer Evolution and Progression.- Cell-cell Fusion as a Mechanism of Immune Evasion and Metastatic Progression.- Implications of Heterotypic Cell Fusion in Cancer.- Investigating the Consequences of Aneuploidy in Cancer and Normal Tissue.- Nano- and Microtubes - Tiny Fusion Events, but Not Overall Plasma Membrane Merger for Exchanging Intracellular Components.- Mathematical Modeling of Cell-cell Fusion Assays to Characterize Virus-Mediated Cell Fusion.
