Description
Cancer cells survive and thrive by radically reshaping the way they use energy, nutrients, and metabolic pathways. This book offers a clear and comprehensive exploration of this rapidly evolving field, revealing how tumors rewire core biochemical processes to sustain proliferation, evade cell death, and adapt to the pressures of the tumor microenvironment. From foundational concepts to cutting edge discoveries, the book provides an essential entry point for understanding the metabolic logic that underlies cancer progression.
Central to this volume is an in depth examination of glutamine metabolism. Alongside this focus, the book extends broadly across the metabolic landscape, covering glycolysis, lipid synthesis and utilization, redox regulation, mitochondrial dynamics, and metabolic communication between cancer cells and their surrounding stromal and immune partners. Each chapter distills mechanistic insight while emphasizing translational relevance, bridging basic science with the latest therapeutic strategies and clinical applications.
Written by leading researchers and clinicians, this book serves as a valuable resource for scientists, oncologists, and drug developers seeking to understand and target the metabolic vulnerabilities of cancer. Whether exploring metabolic reprogramming in cancer stem cells, evaluating biomarkers of metabolic states, or assessing emerging therapies and clinical trial data, readers will gain an integrated perspective on how metabolism shapes tumor behavior and influences treatment outcomes. This is an indispensable guide for anyone committed to advancing cancer research, improving patient care, and translating metabolic insights into meaningful therapeutic advances.
Introduction to Cancer Metabolism.- The Warburg Effect and Aerobic Glycolysis in Tumors.- Glutamine Metabolism: Role in Cancer Cell Proliferation and Survival.- Lipid Metabolism and Oncogenesis.- Redox Regulation and Oxidative Stress in Cancer.- Mitochondrial Metabolism and Dynamics in Tumor Cells.- Metabolic Crosstalk in the Tumor Microenvironment.- Metabolic Reprogramming in Cancer Stem Cells.- Targeting Metabolism in Cancer Therapy: Inhibitors and Approaches.- Biomarkers of Cancer Metabolism and Therapeutic Response.- Immunometabolism and Metabolic Checkpoints.- Tools and Technologies for Studying Cancer Metabolism.- Clinical Trials and Translational Advances in Metabolic Targeting.
Sumel Ashique
Pharmaceutical Technology, Bharat Technology
Howrah, West Bengal, India
Farzad Taghizadeh-Hesary
Assistant Professor,
Breast Cancer Research Center, Iran University of Medical Sciences
Iran University of Medical Sciences
Tehran, Iran
Biplab Debnath
Professor & Principal
Bharat Technology
Uluberia
West Bengal, India
Ayush Madan, B.Tech., M.Tech., DBT-JRF, Ph.D. (p)
Assistant Professor,
Department of Biotechnology,
School of Research & Technology,
People s University, Bhanpur, Bhopal.
Former Graduate Research Assistant,
Institute of Tropical Aquaculture and Fisheries,
Universiti Malaysia Terengganu,
21030 Kuala Nerus, Terengganu, Malaysia
