Description
Now in a revised and expanded second edition, this book provides an up-to-date, comprehensive review of donation after circulatory death (DCD) liver transplantation as well as machine perfusion. Since the time of the original publication, the number of DCD liver transplants in the United States and around the world has grown exponentially. Most notably, machine perfusion techniques such as ex-situ machine perfusion and in-situ normothermic regional perfusion (NRP) have allowed for the utilization of organs that previously would not have been usable.
This comprehensive text will act as a resource for programs that are interested in starting or expanding a DCD liver transplant program, covering history, ethics, current techniques and technologies for resuscitaiton, transplantation and storage, international perspectives, and future directions. In particular, the current edition explores in depth the use of normothermic machine perfusion (NMP), normothermic regional perfusion (NRP), and hypothermic oxygenated perfusion (HOPE) techniques and how they can be leveraged to increase the availability and improve the safety and outcomes when using DCD liver grafts. Chapters have been written by a world-class group of leaders in DCD liver transplant, with a target audience including liver transplant surgeons, medical doctors and any other individuals involved in the transplant process.
1. The History of DCD Liver Transplant.- 2. Ethics and Law of DCD liver transplant and NRP.- 3. Global State of DCD Liver Transplant.- 4. Predicting the likelihood a DCD donor will expire.- 5. Warm Ischemia Time and its Relevance in the Current DCD Liver Transplant Practice.- 6. Ischemia-Reperfusion Injury and Therapeutic Strategies in Donation After Circulatory Death Liver Transplantation.- 7. DCD Liver Transplant Outcomes Over Time.- 8. Ischemic Cholangiopathy.- 9. DCD for complicated recipients.- 10. DCD Standard Rapid Recovery Procurement.- 11. DCD LT with Static Cold Storage.- 12. Back to Base Normothermic Liver Perfusion.- 13. Donor liver resuscitation with machine perfusion using modulated temperature.- 14. Hypothermic Oxygenated Perfusion.- 15. Developing an NRP Program.- 16. NRP Circuit and Perfusion: Management and Troubleshooting.- 17. Simultaneous Standard Recovery of the Lungs and Abdominal Normothermic Regional Perfusion For Recovery of the Abdominal Organs in Controlled Donation after Circulatory Death.- 18. Simultaneous Standard Recovery of the Heart and Abdominal Normothermic Regional Perfusion for Recovery of the Abdominal Oragns in Controled Donation After Circulatory Death.- 19. NRP an American Perspective.- 20. Normothermic Regional Perfusion: a European Perspective.- 21. TA-NRP and Abdominal Recovery.- 22. OPO based NRP Recovery.- 23. Viability assessment of DCD livers.- 24. DCD liver transplantation from uncontrolled donors.- 25.Anaesthesia Perspective of DCD liver transplant.- 26. DCD liver allocation current and future direction.
Kristopher P. Croome, MD, Department of Transplant, Mayo Clinic Florida, Jacksonville, FL, USA
Gabriel C. Oniscu, MD, FRCS(Ed), Division of Transplantation Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
C. Burcin Taner, MD, Department of Surgery, Transplant Center, Mayo Clinic, Jacksonville, FL, USA
