The Pharmaceutical Applications of Dimethyl Sulfoxide : From Skin Penetration to Cell Therapy (AAPS Advances in the Pharmaceutical Sciences Series)

Langley, NigelEDT/ Almarsson, OErnEDT/ Osborne, DavidEDT

Springer, Berlin; Springer（2026/07発売）

• 製本 Hardcover:ハードカバー版
• 商品コード 9783032192554

Full Description

This book provides an in-depth educational review of Dimethyl Sulfoxide (DMSO) and its utility in pharmaceutical drug development with specific focus on topical, parenteral, and biologics applications and formulations. Dimethyl sulfoxide is a widely used but often under-appreciated pharmaceutical material, which is perceived to be primarily confined to discovery research. This book helps to change this perception. This book brings current awareness of this multifunctional material as an API and excipient. This book also summarizes the safety and toxicology of dimethyl sulfoxide as it compares to other aprotic solvents. The intended audience is pharmaceutical scientists, pharmaceutical formulators, researchers, drug development professionals and academics.

Contents

Introduction Scope of the book.- Physical and chemical properties of Dimethyl Sulfoxide.- Toxicology and Safety vs other aprotic solvents.- Skin Penetration enhancers in topical pharmaceutical drug development.- Skin penetration mechanism and mode of action of Dimethyl Sulfoxide.- Formulated topical drug products case studies.- Dimethyl Sulfoxide as an active pharmaceutical ingredient API.- Dimethyl Sulfoxide as a cryoprotectant.- Cell and Gene Therapy.- Subcutaneous delivery of highly concentrated and viscous biologics drugs.- Long Acting Injectable drug formulations.- mRNA vaccines.- Oral drug applications.