Full Description
This book offers readers a comprehensive exploration of the critical role that metabolic remodeling plays in cancer cell survival and progression. Faced with persistent stress, such as nutrient deprivation, hypoxia, and immune pressure, cancer cells rely on the tumor microenvironment (TME) as a key driver of metabolic adaptation.
This edited volume presents a multidisciplinary view of cancer metabolism as a strategic tool employed by cancer cells to adapt and thrive within the TME. It examines the TME and organ-specific microenvironments as complex, integrated systems, encompassing not only cancer cells, but also stromal components and the microbiota. This intricate network is explored not only as a driver of tumor development and therapy resistance but also as a rich source of targetable vulnerabilities. By shifting the lens from cancer cells alone to their interactions with the surrounding environment, this book highlights emerging molecular players and mechanisms that may enable next-generation cancer therapies, as well as metabolism-informed tools for diagnosis and prognosis.
Written by leading experts in the field, this work is intended for researchers interested in cancer biology, the tumor microenvironment, cancer metabolism, and therapeutic innovation. It will appeal to basic and translational scientists, analytical researchers, bioengineers, and clinicians engaged in oncology research and practice.
Contents
Chapter 1: The interdependence of carbon substrates and metabolic pathways enables the metabolic plasticity of cancer cells.- Chapter 2: Glucose and lactate, starters or intermediates of cancer metabolic rewiring.- Section 1: Metabolic adaptation a way of surviving to stressful conditions of the tumor microenvironment.- Chapter 3: Metabolism-Driven Modulation by the Human Microbiota: Implications for Cancer Therapy and Emerging Strategies.- Chapter 4: Gut-liver microbiome and tumor microenvironment in metabolic dysfunction-associated steatotic liver disease.- Chapter 5: Metabolic Reprogramming in the Bladder Cancer Microenvironment: Bridging Fundamental Research and Therapeutic Avenues for Cancer-associated Fibroblasts.- Chapter 6: Metabolic Symbiosis between Cancer Cells and Endothelial Cells: A Key Driver of Tumor Angiogenesis.- Chapter 7: Immunity and Beyond: Emerging Roles of Monocytes and Macrophages in Cancer.- Chapter 8: Dissecting Cancer Metabolism and Therapeutic Resistance Using In Vitro Platforms.- Section 2. Genetics and epigenetics- the way cancer cells control metabolism and survival.- Chapter 9: Epigenetics and One-Carbon Metabolism in Cancer: Mechanisms and Therapeutic Implications.- Chapter 10: Cell-free DNA (cfDNA), its applications in cancer diagnosis and monitoring, and its potential role in regulating cancer metabolism.- Chapter 11: Influence of RNA Modifications on Cancer Metabolism: Interplay with Hypoxia and Therapeutic Implications.- Chapter 12: Epigenetics in Myeloid Malignancies: from basic biology to complex clinical applications.- Chapter 13: Epigenetic targeting in myeloid malignancies.- Section 3. Metabolic fitness to overcome therapy.- Chapter 14: The metabolic remodelling in lung cancer and its putative consequence in therapy response.- Chapter 15: Cysteine metabolism in the control of oxidative stress in cancer, focusing carbon and sulfur metabolism.- Chapter 16: Fueling Death: The Metabolic Control of Ferroptosis.- Chapter 17: Mitochondrial energy metabolism in cancer, immunoregulation and anti-tumour response.- Chapter 18: Use of Nuclear Magnetic Resonance (NMR) to study cancer metabolism.- Chapter 19: Mass spectrometry as a tool for metabolomics in cancer.- Chapter 20: Cysteine metabolism as a central metabolic driver and selenocompounds as therapeutic agents.- Chapter 21: Metabolic Control of Immunity: Unveiling Neutrophil Mechanisms.- Chapter 22: Lipid Remodelling and Metabolic Adaptation in Cancer Cell Membranes: A Platform for Membrane.- Section 6. New tools for a translational application of cancer metabolism.- Chapter 23: Mathematical Modeling in Cancer Metabolism: Tools for Translational Applications in Metabolism-Based Therapy.
