Full Description
This book offers a comprehensive overview on the topic of liver regeneration with the aim of providing a potentially curative surgical treatment for liver tumours. it will be divided into five thematic sessions: from the cellular and haemodynamic mechanisms that act as triggers for the regeneration process, to currently available techniques based on surgical and/or interventional radiology methods, their optimisation and risks, to a discussion of how to use hypertrophy techniques in the context of each specific disease setting and new frontiers. Despite the fact that this is a progressively evolving field, the importance of performing major liver resections in a safe setting - reducing the risk of post-operative liver failure, which is the most serious potentially life-threatening complication in liver surgery - will remain unchanged in the field of cancer surgery. In this scenario, a book providing a systematic discussion of the state of the art and evidence now established in this field is an essential tool for any centre with an active liver surgery programme. The multidisciplinary perspective used to address this topic is a further innovative value of this project, which has the ambition of meeting the need for a lasting cultural background on this subject.
Contents
Preface.- Foreward.- Mechanisms of liver regeneration.- Microbiota and liver-gut axis in liver regeneration.- Hemodynamic basis of liver regeneration.- Metabolic factors affecting liver regeneration.- Pathogenesis of postoperative liver failure.- Diagnosis and classification of postoperative liver failure.- Volumetric study of the liver and cutoffs for a safe liver surgery.- Functional study of the liver: imaging tests.- Functional study of the liver: non-imaging tests.- Portal vein embolization.- Portal vein ligation.- Two stage hepatectomy.- ALPPS.- Hepatic deprivation.- Radioembolization.- Rationale and techniques for liver hypertrophy in colorectal liver metastases.- Hypertrophy techniques in synchronous colorectal liver metastases.- Hypertrophy techniques in hepatocellular carcinoma.- Hypertrophy techniques in cholangiocarcinoma.- Hypertrophy techniques in transplant setting.- Impact of minimally-invasive approaches.- The issue of drop out.- Management of postoperative liver failure.- future of regenerative hepatology.
